您目前的位置:院首页» 首页» English» Research Supervisor

ZHANG Liangren

Professor

   

 

 

 

 

ZHANG Liangren

Professor of Medicinal Chemistry

State Key Laboratory of Natural and Biomimetic Chemistry,

School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Rd., Beijing 100191

Tel: 0086-10 82802567;  E-Mail: liangren@bjmu.edu.cn

Education and Experience

1983                    BS, Hunan Normal University

1986                   MS, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences

1991                   PhD, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences

1988-1990          Joint Ph.D. student, Faculty of Engineering, Kyushu University, Fukuoka, Japan

1991-1993           Post-doctoral Research Fellow, Beijing Medical University (mergered with Peking University in 2000)

1994-1997           Associate Professor, Beijing Medical University

1998.1-1998.10   Visiting Research Scientist, University of California at San Francisco, USA

1999.11-2000.1   Visiting Research Scientist, University of Michigan, USA

2000-2002           Associate professor, School of Pharmaceutical Sciences, Peking University

2002-present              Professor, Peking University

2007.1-2007.2     Visiting Professor, School of Pharmaceutical Sciences, Kyushu University, Japan

Honors and Awards

1.      Member of American Chemical Society

2.      Member of Chinese Pharmaceutical Science and Vice Director of the division of medicinal chemistry.

3.      Editor of “Journal of Chinese Pharmaceutical Sciences”, “Chinese Journal of Medicinal Chemistry”, “Chinese Pharmacetival Journal”, “Acta Pharmaceutica Sinica”, “Drug Discovery & Therapeutics”, etc.

4.      National Awards of Natural Sciences, 2nd class, 2004

Research Interests

1.      Design, synthesis and structural optimization of therapeutic agents

2.      Synthesis of Nucleoside, nucleotide, and oligonucleotide

3.      Rational design of anti-tumor and anti-virus drugs

4.      Quantitative structure-activity relationship and structural optimization of lead compound.

Research Project

1.      Natural Products derived CXCR4/CCR2 dual targeted fusion inhibitors. Natural Science Foundation of China (NSFC)-NIH joint foundation, 2012.1-2012.12, Co-investigators/ Project Director.

2.      Studies on the synthesis and physiology of inhibitors of calcium related multi-functional CD38. NSFC, 2012-2015. Principle Investigator.

3.      Identifying novel regulators in cADPR-mediated calcium signaling by combining approaches of synthetic organic chemistry and genome-wide RNAi screen NSFC/Hong Kong RGC Joint Research Foundation, 2010-2012. Co- Principle Investigator.

4.      Discovery and lead optimization of VIF targeted anti-HIV-1 agents. NSFC, 2010-2012. Principle Investigator.

5.      Calcium signaling pathway regulated by nucleotide and its analogues. NSFC, 2008-2014. Principle Investigator.

6.      Design and synthesis of anti-cancer agents targeted to proteasome. NSFC, 2007-2009. Principle Investigator.

Publication List

1.        Analysis of the interactions of ribonuclease inhibitor with kanamycin. Zhanli Wang, Liangren Zhang, Jingfen Lu, Lihe Zhang, Journal of Molecular Modeling, 2005, 11, 80-86.

2.        A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells. Andreas H. Guse, Xianfeng Gu, Liangren Zhang, Karin Weber, Elisabeth Kr?mer, Zhenjun Yang, Hongwei Jin, Qin Li, Lucie Carrier, and Lihe Zhang, Journal of Biological Chemistry, 2005, 280, 15952-15959.

3.        Properties of isonucleotide incorporated oligodeoxynucleotides and inhibition to the expression of spike protein of SARS-CoV. Zhanli Wang, Jifeng Shi, Hongwei Jin, Liangren Zhang*, Jingfeng Lu, Lihe Zhang, Bioconjugate Chemistry, 2005, 16, 1081-1087.

4.        Selective deacetylation using iodine-methanol reagent in fully acelylated nucleosides. Bo Ren, Li Cai, Liang-Ren Zhang, Zhen-Jun Yang and Li-He Zhang, Tetrahedron Letters, 2005, 46, 8083-8086.

5.        Structural insights into the effect of isonucleosides on B-DNA duplexes using molecular dynamics simulations. Hongwei Jin, Suxin Zheng, Zhanli Wang, Cheng Luo, Jianhua Shen, Hualiang Jiang, Liangren Zhang*, Lihe Zhang, Journal of Molecular Modeling, 2006, 12, 781-791.

6.        Parametrization of a specific free energy function for automated docking against RNA targets using neural networks.  Florent Barbault, Liangren Zhang, Lihe Zhang and Bo Tao Fan, Chemometrics and Intelligent Laboratory Systems, 2006, 82, 269-275.

7.        One-step synthesis of novel tricyclic isomeric azidonucleosides.  Zong-Sheng Li, Ren-Ping Qiao, Zhen-Jun Yang, Liang-Ren Zhang and Li-He Zhang, Tetrahedron: Asymmetry, 2006, 17, 1056-1061.

8.        Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.  Jianfeng Xu, Zhenjun Yang, Werner Dammermann, Liangren Zhang*, Andreas H. Guse, and Li-he Zhang, Journal of Medicinal Chemistry, 2006, 49, 5501-5512.

9.        Three-dimensional structure of HIV-1 VIF constructed by comparative modeling and the function characterization analyzed by molecular dynamics simulation.  Wei Lv, Zhenming Liu, Hongwei Jin, Xianghui Yu, Liangren Zhang* and Lihe Zhang, Organic & Biomolecular Chemistry, 2007, 5, 617-626.

10.    Pharmacophore modeling and in silico screening for new KDR kinase inhibitors.  Hui Yu, Zhanli Wang, Liangren Zhang, Jufeng Zhang and Qian Huang, Bioorganic & Medicinal Chemistry Letters, 2007, 17, 2126-2133.

11.    Synthesis and recognition of novel isonucleoside triphosphates by DNA polymerases. Caiwu Jiang, Bingchao Li, Zhu Guan, Zhenjun Yang, Liangren Zhang and Lihe Zhang, Bioorganic & Medicinal Chemistry, 2007, 15, 3019-3025.

12.    Investigation of the binding behavior of human serum albumin and phosphorothioate oligodeoxynucleotide. Guo-Zhu Ye, Liang-Ren Zhang* and Li-He Zhang, Journal of Chinese Pharmaceutical Science, 2007, 16, 9-13.

13.    Investigation of the binding behaviors of isonucleoside-incorporated oligonucleotides with complementary sequences.  Zhu Guan, Hong-Wei Jin, Zhen-Jun Yang, Liang-Ren Zhang*, Li-He Zhang, Drug Discovery & Therapeutics, 2007, 1, 65-72.

14.    Studies on aminoisonucleoside modified siRNAs: stability and silencing activity.  Zong-Sheng Li, Ren-Ping Qiao, Quan Du, Zhen-Jun Yang, Liang-Ren Zhang, Pei-Zhuo Zhang, Zi-Cai Liang, and Li-He Zhang, Bioconjugate Chemistry, 2007, 18, 1017-1024.

15.    Synthesis of aminodisaccharide–nucleoside conjugates for RNA binding.  Li Cai, Qin Li, Bo Ren, Zhen-Jun Yang, Liang-Ren Zhang and Li-He Zhang, Tetrahedron, 2007, 63, 8135-8144.

16.    A concise synthesis of 4,6-dideoxy-4-base-6-amino-2,5-anhydro-L-mannitols.  Fang Wang, Zhen-Jun Yang, Hong-Wei Jin, Liang-Ren Zhang and Li-He Zhang, Tetrahedron: asymmetry, 2007, 18, 2139-2146.

17.    Efficient synthesis of 8-oxa-bicyclo[-->3.2.1]octane derivatives from D-arabinose.  Yi Liu, Tian-Xiang Han, Zhen-Jun Yang, Liang-Ren Zhang, Li-He Zhang, Tetrahedron: asymmetry, 2007, 18, 2326-2331.

18.    Synthesis of novel ADPR analogues: substitution of pyrophosphate linkage by dipeptide. Chao Zhang, Zhen-Jun Yang, Liang-Ren Zhang*, Li-He Zhang, Journal of Chinese Pharmaceutical Sciences, 2007, 16, 262-267.

19.    Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor.  Mengyao Li, Yanjie Li, Jiejin Chen, Wei Wei, Xiaowei Pan, Jing Liu, Qingyu Liu, Wei Leu, Liangren Zhang, Xiaoda Yang, Jingfen Lu, and Kui Wang, Biochemistry, 2007, 46, 11451-11458.

20.    Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein.  Jufeng Zhang, Zhanli Wang, Fang Wei, Wei Qiu, Liangren Zhang, Qian Huang, Biochemical and Biophysical Research Communications, 2007, 360, 46-50.

21.    Adenine Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic ADP-ribose Analogues.  Liangren Zhang*, Zhenjun Yang, Andreas H. Guse and Lihe Zhang, Pure and Applied Chemistry, 2008, 80, 1821-1825.

22.    Synthesis and properties of a new SASRIN resin derivative: SASRIN-2-pyridylthiocarbonate (SASRIN-TOPCAT) resin.  Peng Zhao, Zhen Jun Yang, Liang Ren Zhang, Li He Zhang, Tetrahedron Letters, 2008, 49, 2951-2955.

23.    In vitro selection of G-rich RNA aptamers that target HIV-1 integrase.  YingChun Liu, Yan Zhang, GuoZhu Ye, ZhenJun Yang, LiangRen Zhang and LiHe Zhang, Science in China Series B: Chemistry, 2008, 51, 401-403.

24.    A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry.  Lingjun Li, Baichuan Lin, Zhenjun Yang, Liangren Zhang, Lihe Zhang, Tetrahedron Letters, 2008, 49, 4491-4493.

25.    Stereospecific synthesis of eight-membered multihydroxyl carbocycle via TIBAL-promoted Claisen rearrangment.  Tianxiang Han, Yi Liu, Zhenjun Yang, Liangren Zhang*, Lihe Zhang, Synlett, 2008, (13), 1985-1988.

26.    Ligand-free Pd-catalyzed highly selective arylation of allylic esters with retention of the traditional leaving group.  Delin Pan, Anjun Chen, Yijin Su, Wang Zhou, Si Li, Wei Jia, Juan Xiao, Qingjian Liu, Liangren Zhang, Ning Jiao, Angewandte Chemie International Edition, 2008, 47, 4729-4732.                               

27.    Flexible computational docking studies of new aminoglycosides targeting RNA 16S bacterial ribosome site.  Florent Barbault, Bo Ren, Joseph Rebehmed, Catia Teixeira, Yun Luo, Ornella Smila-Castro, Fran?ois Maurel, BoTao Fan, Liangren Zhang*, Lihe Zhang, European Journal of Medicinal Chemistry, 2008, 43, 1648-1656.

28.    Solid-phase synthesis and evaluation of TAR RNA targeted-carboline-nucleoside conjugates. Peng Zhao, Hong-Wei Jin, Zhen-Jun Yang, Liang-Ren Zhang and Li-He Zhang, Organic & Biomolecular Chemistry, 2008, 6, 3741-3750.

29.    Synthesis of 2S-(2-hydroxyethyl)-3R-hydroxy-4S-(thymin-1-yl or adenin-9-yl)-tetrahydro- furan.  Ying-Chun Liu, Jun Zhang, Lei Xing, Zhen-Jun Yang, Liang-Ren Zhang, Li-He Zhang, Tetrahedron, 2008, 64, 9630-9635.

30.    Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA.  Hui Mei, Lei Xing, Li Cai, Hong-Wei Jin, Peng Zhao, Zhen-Jun Yang, Liang-Ren Zhang, Li-He Zhang, Bioorganic & Medicinal Chemistry Letters, 2008, 18, 5355-5358.

31.    N-(2,6-Dimethoxypyridine-3-yl)-9-Methylcarbazole-3-Sulfonamide as a Novel Tubulin Ligand against Human Cancer. Yue-Ming Wang, Lai-Xing Hu, Zhen-Ming Liu, Xue-Fu You, Sheng-Hua Zhang, Jing-Rong Qu, Zhuo-Rong Li, Yan Li, Wei-Jia Kong, Hong-Wei He, Rong-Guang Shao, Liang-Ren Zhang, Zong-Gen Peng, David W.oykin, Jian-Dong Jiang.      Clinical Cancer Research, 2008, 14, 6218-6227. 

32.    Studies on modified oligonucleotides. Li He Zhang, Zhen Jun Yang, Liang Ren Zhang.    Phosphorus, Sulfur and Silicon and the Related Elements, 2008, 183, 326-334.

33.    Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity.  Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, Xiaowei Wang, Zhenming Liu, Liangren Zhang, Jingrong Cui, Junyi Liu, European Journal of Medicinal Chemistry, 2009, 44, 764-771.

34.    Synthesis and Evaluation of Novel Neamine Derivatives Effectively effectively targeting to RNA.  Yanli Xu, Hongwei Jin, Zhenjun Yang, Liangren Zhang, Qi Wang, Manning Li and Lihe Zhang, Bioorganic & Medicinal Chemistry Letters, 2009, 19, 2103-2106.

35.    The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3,4-dihydroquinolin-2-ones.  Wang Zhou, Liangren Zhang, Ning Jiao, Tetrahedron, 2009, 65, 1982-1987.

36.    Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature.  Wang Zhou, Liangren Zhang, Ning Jiao, Angewandte Chemie International Edition, 2009, 48, 7094-7097.

37.    Synthesis and biological evaluation of novel neamine-nucleoside conjugates potentially targeting to RNAs. Yanli Xu, Hongwei Jin, Zhenjun Yang, Liangren Zhang, Lihe Zhang, Tetrahedron, 2009, 65, 5228-5239.

38.    Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease.  Guan-Nan Wang, Gabriele Reinkensmeier, Si-Wei Zhang, Jian Zhou, Liang-Ren Zhang, Li-He Zhang, Terry D. Butters and Xin-Shan Ye, Journal of Medicinal Chemistry, 2009, 52, 3146-3149.

39.    Covalent complexes of proteasome model with peptide aldehyde inhibitors MG132 and MG101: docking and molecular dynamics study. Siwei Zhang, Yawei Shi, Hongwei Jin, Zhenming Liu, Liangren Zhang*, Lihe Zhang, Journal of Molecular Modeling, 2009, 15, 1481-1490.

40.    An efficient synthesis of (R)-and (S)-baclofen via desymmetrization.  Lei Ji, Yuheng Ma, Jin Li, Liangren Zhang*, and Lihe Zhang, Tetrahedron Letters, 2009, 50, 6166-6168.

41.    The CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays NGF induced differentiation in PC12 cells.  Jianbo Yue, Wenjie Wei, Connie M. C. Lam, Yong-Huan Zhao, Min Dong, Liang-