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ZHANG Lihe

 

 

 

 

ZHANG Li-HeCHANG Li-ho

University Education:

1964-1967    Graduate School, Beijing Medical College, Major in Med. Chem.

1954-1958    Department of Pharmacy, Beijing Medical College, China

 

Professional Experience:

2006-date     President, Academic Committee of State Key Laboratory of Natural & Biomimetic Drugs,

Peking University

2000-date     Professor of Medicinal Chemistry, Peking University

1992-2006    Director, State Key Laboratory of Natural and Biomimetic Drugs, Peking University

1998-2006    Director, Chemistry Department, National Natural Science Foundation of China
1986-2000    Dean, Professor of Medicinal Chemistry, School of Pharmaceutical Sciences,

Beijing Medical University

1983-1986    Associate Professor, School of Pharmaceutical Sciences, Beijing Medical University

1981-1983    Research Associate, Department of Chemistry, University of Virginia, USA

1967-1981    Lecturer, Department of Pharmacy, Beijing Medical College

1958-1964    Assistant, Department of Pharmacy, Beijing Medical College

 

Research Areas:      

Chemistry of Nucleosides and Nucleotides;

Anticancer and Antiviral Drugs;

Natural Products.

 

Scientific Society & other committee activities:

Titular Member, IUPAC, Division III, Biomolecular Chemistry Committee (2006-2008);

Fellow, Royal Society of Chemistry ( 2006-);

Member, Chinese Chemical Society;

Vice-President, Chinese Pharmaceutical Association(1997-2001); 

President, Asian Federation for Medicinal Chemistry(1998-2000) 

 

Editorial Boards:   

Member, Internat. Adv. Editorial Board, Organic & Biomolecular Chemistry (2006-), ChemMedChem (2007-),  Medicinal Research Review (2004-), Current Topics of Medicinal Chemistry (2000-).

 

Awards:

2009      Nagai-Hisamitsu Outstanding Science Award, Asia Pharmaceutical Association, Kyoto, Japan

2004      Natural Science Award, Second Prize, Ministry of Science and Technology. China

2002      Science and Technology Award, Second Prize, awarded by The Ministry of Education, China

2000      Millennium Pharmaceutical Scientist Award, FIP, San Francisco, USA

1999      He-Liang-He-Li Prize

1998      Science and Technology Award, First Prize, awarded by The Ministry of Education, China

1996      Science and Technology Award, Second Prize, awarded by The Ministry of Education, China

1995      Member, Chinese Academy of Sciences

1993      12th Edgar Snow Professorship, awarded by Edgar Snow Foundation and University of Missouri,

Kansas City, USA

1993      Colorcon Award, International Symposium of International Pharmaceutical Association, Tokyo, Japan

1990      Honorary Doctorate, Hoshi University, Japan

1988      Otani Prize, awarded by Hoshi University, Japan

1980      Beijing Science and Technology Prize, awarded by Beijing City Government, China

1964      National Award for Scientific Research Excellence, State Commission Science & Technology, China

 

Publications;   over 250 in refereed journals.

Nucleic Acids Res. 2002, 30 (13), 3005-3014; Bioconjugate Chem., 2003, 14 (3), 532-538; J. Med. Chem., 2004, 47, 5674-5682; J. Cell Science, 2004, 117, 2141-2149; J. Biol. Chem., 2005, 280, 15952-15959;  J. Med. Chem., 2006, 49 (19), 5501-12; Medicinal Research Reviews, 2007, 27 (3), 279-316; J. Org. Chem., 2008, 73, 3630; Synlett, 2008, 13, 1985.

 

Selected Publications:

1.        Synthesis and biological evaluation of novel neamine–nucleoside conjugates potentially targeting to RNAs. Yanli Xu, Hongwei Jin, Zhenjun Yang, Liangren Zhang, Lihe Zhang, Tetrahedron, 2009, 65, 5228-5239.

2.        Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs. Huang Huang, Renping Qiao, Deyao Zhao, Tong Zhang, Youxian Li, Fan Yi, Fangfang Lai, Junmei Hong, Xianfeng Ding, Zhenjun Yang, Lihe Zhang, Quan Du, and Zicai Li,  Nucleic Acids Res., 2009, 37 (22), 7560-7569.

3.        A method for detecting and preventing negative RNA interference in preparation of lentiviral vectors for siRNA delivery. Demin Zhou, Jing Zhang, Cuiying Wang, J. Bliesath, Qiuchen He, Dehua Yu, Lihe Zhang and F. Wong-Staal, RNA, 2009,