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梁磊

副教授

理学博士,副教授,硕士生导师

电话:+86-10-82801505 邮箱:leiliang@bjmu.edu.cn

 

学习经历

2000.9-2004.7  四川大学化学学院(理学学士)

2004.9-2009.7  四川大学-美国伊利诺依大学UIUC(联合培养博士)

 

工作经历

2009.7-2011.6  北京大学化学与分子工程学院(博士后)

2011.7-2014.7  北京大学药学院讲师

2014.8-至今    北京大学药学院副教授,硕士生导师

 

研究方向

1. 基于靶点的药物设计、合成与构效关系研究

2. 分子探针的设计及生物学应用

 

奖励

1.  2012年北京大学药学院第十二届青年教师教学演示竞赛一等奖

2.  2012年北京大学第十二届青年教师教学演示竞赛二等奖

 

科研成果

1. Tongliang Zhou, Lingfei Yang, Lei Liang,* Hui Liu, Yuanjun Zhu,* Mengyang Shui, Lan Yuan,* Fengrong Xu, Yan Niu, Chao Wang, and Ping Xu,* Rational Design of a Near-infrared Fluorescent Probe Based on Pyridazinone Scaffold. Eur. J. Org. Chem ., 2017, 3274-3281.

2. Yuanjun Zhu, Tongliang Zhou, Lingfei Yang, Lan Yuan, Lei Liang,* Ping Xu,* Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochem & Biophy Res. Comm., 2017 , 486, 904-908.

3.  Hongyue Li, Tongliang Zhou, Hui Liu, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Discovery of a cobalt complex with high MEK1 binding affinity. Bioorg. Med. Chem. Lett., 2017, 27 , 2221-2224.

4.  Tongliang Zhou, Yuanbo Cai, Lei Liang,* Lingfei Yang, Fengrong Xu, Yan Niu, Chao Wang, Junlong Zhang,* Ping Xu,* Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes. Bioorg. Med. Chem. Lett., 2016, 26 , 5780-5784.

5.  Lingfei Yang, Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Jun-Long Zhang, Ping Xu,* Lan Yuan,* and Lei Liang,* Rational design of fluorescent phthalazinone derivatives for one- and two-photon imaging. Chem. Eur. J., 2016, 22 , 12363-12370.

6.  Lingfei Yang, Wei Wang, Qi Sun, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorg. Med. Chem. Lett. 2016, 26 , 2801-2805.

7.  Wei Wang, Lei Liang,* Fengrong Xu, Wenjie Huang, Yan Niu, Qi Sun, Ping Xu,* Ruthenium-Catalyzed Switchable N–H/C–H Alkenylation of 6-Phenyl(dihydro)pyridazinones with Alkynes. Eur. J. Org. Chem . 2014, 6863–6867.

8.  Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu*, Ping Xu*, Rational Design, Green Synthesis, and Initial Evaluation of a Series of Full-Color Tunable Fluorescent Dyes Enabled by the Copper-Catalyzed N-Arylation of 6-Phenyl Pyridazinones and Their Application in Cell Imaging. Chem. Eur. J. 2013, 19 , 13774-13782.

9.  Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation. Org. Lett , 2013, 15 , 2770-2773.

10. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, A Copper-Catalyzed Aerobic Cascade Dehydrogenative Dehalogenative Reaction. Adv. Syn&Cat , 2013, 355 , 1284-1290.

11. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Copper-Catalyzed Aerobic Dehydrogenation of C–C to C="C" Bonds in the Synthesis of Pyridazinones. Eur. J. Org. Chem . 2013, 6130–6136.

12. Lei Liang, H. Lv, Y. Yu, P. Wang, J.-L. Zhang *, Iron(III) tetrakis(pentafluorophenyl)porpholactone catalyzes nitrogen atom transfer to C="C" and C-H bonds with organic azides. Dalton Trans., 2012, 41 , 1457-1460.

13. Lei Liang, G. Rao, H.-L. Sun, J.-L. Zhang *, Aerobic Oxidation of Primary Alcohols Catalyzed by Copper Salts and Catalytically Active m-Hydroxyl-Bridged Trinuclear Copper Intermediate. Adv. Synth. Catal., 2010, 352 , 2371-2377.