牛彦 理学博士，副教授，博士生导师
办公电话: +86-10-82805281 电子邮箱: yanniu@bjmu.edu.cn
学习及工作经历
2021.12-今 北京大学药学院，药物化学系，副教授，博士生导师
2015.9-2016.9 德国康斯坦茨大学化学生物学与药理学系，访问学者
2013.8-2021.12北京大学药学院，药物化学系，副教授，硕士生导师;
2007.8-2013.7 北京大学药学院，药物化学系，讲师;
2002.9-2007.7 北京大学药学院，化学生物学专业，博士;
1998.9-2002.7 北京大学药学院，药学专业，本科。
讲授课程
《药物化学》、《药物化学进展》、《计算机辅助药物设计》。
研究方向与兴趣
1. 药物先导化合物的发现和优化；
2. 基于靶标结构的药物分子设计与化学合成；
3. 活性小分子构效关系研究
获得奖励
1. 2023年，北京大学医学部教学优秀奖；
2. 2019年，北京大学绿叶生物医药杰出青年学者奖；
3. 2017年， 北京大学第17届青年教师教学基本功比赛（医科类），优秀奖；
4.2010年，北京大学优秀班主任，二等奖
代表性论文
1. Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu* and Yan Niu*, Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Biochem Pharmacol . 2022, 197:114913.
2. Xiaona Li, Zirui Lü, Cong Wang, Kebin Li, Fengrong Xu, Ping Xu*, and Yan Niu*, Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules, ACS Med Chem Lett , 2021, 12(5): 720-725.
3. Zirui Lü, Xiaona Li, Kebin Li, Cong Wang, Tingting Du, Wei Huang, Ming Ji, Changhong Li, Fengrong Xu, Ping Xu*, and Yan Niu*，Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitors. ACS Med Chem Lett , 2021, 12(5):696-703.
4. Sun Q, Zhou T, Xi D, Li X, LüZ, Xu F, Wang C, Niu Y*, Xu P.*，Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem . 2020,192: 112160. https://doi.org/10.1016/j.ejmech.2020.112160
5. Dandan Xi, Yan Niu*, Hongyue Li, Stefan M. Noha, Veronika Temml, Daniela Schuster*, Chao Wang, Fengrong Xu, and Ping Xu*, Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening, Eur J Med Chem , 2019, 178: 802-817. https://doi.org/10.1016/j.ejmech.2019.06.027
6. Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*, Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Bioorg Med Chem , 2016, 24: 3472–3482.
其他论文
1. Li C, Wang F, Han Y, Zhai J, Jin Y, Liu R, Niu Y, Yao Z, Zhao J, Nitazoxanide reduces inflammation and bone erosion in mice with collagen-induced arthritis via inhibiting the JAK2/STAT3 and NF-κB pathways in fibroblast-like synoviocytes. Biomed Pharmacother . 2024, 171:116195. doi: 10.1016/j.biopha.2024.116195. PMID: 38262149
2. Wang Y, Zou W, Niu Y, Wang S, Chen B, Xiong R, Zhang P, Luo Z, Wu Y, Fan C, Zhong Z, Xu P, Peng Y. Phosphorylation of enteroviral 2Apro at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis. J Med Virol . 2023 Jan;95(1): e28400. doi: 10.1002/jmv.28400.
3. Chang-hong Li, Zi-ruiLü, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng*, Yan Niu* and Mo-pei Wang*, Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis, Frontiers in Pharmacology, 2021, 12: 781640, doi: 10.3389/fphar.2021.781640
4. P. Ripani, J. Delp, K. Bode, M. E. Delgado, L. Dietrich, V. M. Betzler, Y. Niu, G. von Scheven, T. U. Mayer, M. Leist & T. Brunner*, Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain, Oncogene , 2020, 39: 2345–2357.
5. Xiufeng Xu, Peng Lü, Junjie Wang, Fengrong Xu, Lei Liang, Chao Wang, Yan Niu*, and Ping Xu*, Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors, Chem. Biol. Drug Des. , 2019, 93(5): 926-933. doi: 10.1111/cbdd.13489.
6. Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*, 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, Eur J MedChem , 2017, 137: 462–475.
7. Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin*, Ping Xu*. Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors. ChemMedChem , 2015, 10, 498–510.
8. Peng Liu, Yan Niu*, Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu,Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*, 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies, Eur J MedChem. 2014, 79: 413- 421.
9. Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu*, Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents, Molecules , 2013, 18, 6057-6091.
10. Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors, Letters in Drug Design & Discovery , 2013, 10 ( 4 ): 297-302.
11. Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors, Chem Biol Drug Des , 2012, 80: 775–780.
12. Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies, Chem Biol Drug Des , 2012, 79:972-80.
13. Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu, Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline, Biochemical and Biophysical Research Communications , 2011, 410: 229–234
14. Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry. 2010, 45: 2089–2094.
15. Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice, Neuroscience Letters , 2010, 473: 115–119.
16. Yihui Cui, Dong Wang, Wen Si, Wen Lu, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline, Cell Research , 2008: 1-3.
发明专利
1. 靶向BCR-ABL的降解剂及其应用，中国专利：202381338165.5，发明人：牛彦，徐萍，孙辉，胡恒杰，李丛 (已转让)
2. 噻唑类化合物在制备治疗和预防癌症药物中的用途，PCT/2022CN/000051，发明人：牛彦，徐萍，许凤荣，吕子睿
3. 硝唑尼特及其衍生物在制备预防和治疗骨破坏性疾病药物中的用途，中国专利：202110356277.8，发明人：李常虹，牛彦，徐萍，王墨培
