熊德彩 研究员
E-mail: decai@bjmu.edu.cn
Tel: 010-82805732
教育及工作经历
2001.8-2005.7 理学学士，兰州大学化学化工学院化学基地班
2005.8-2010.7 理学博士，北京大学药学院化学生物学系，导师：叶新山教授
2010.8-至今 助理研究员、副研究员、研究员、博士生导师，北京大学药学院、天然药物及仿生药物国家重点实验室
研究方向
光/电驱动的糖化学反应研究
糖基化新方法和新策略
生物活性寡(聚)糖和糖模拟物的合成及活性评价
科研项目
2022.01-2025.12，国家自然科学基金面上项目，项目负责人
2020.01-2023.12，国家自然科学基金面上项目，项目负责人
2018.01-2021.12，国家自然科学基金面上项目，项目负责人
2016.01-2019.12，国家自然科学基金面上项目，项目负责人
2019.01-2020.12，国家科技重大专项重大新药创制，子课题负责人
2014.01-2016.06，北京市自然科学基金，项目负责人
2012.01-2014.12，国家自然科学基金青年科学基金项目，项目负责人
荣誉奖励
2021年 国家人才计划青年项目入选者
2020年 北京大学医学部优秀共产党员
2018年 北京大学绿叶生物医药杰出青年学者奖
2016年 北京大学医学部优秀共产党员
2015年 北京大学医学部优秀教师
2015年 北京大学医学部青年岗位能手
2013年 国家自然科学二等奖 (第二完成人)
2011年 中国药学会科学技术一等奖 (第二完成人)
2010年 教育部高等学校自然科学二等奖 (第二完成人)
兼职与服务
中国疫苗行业协会糖疫苗专业委员会常务委员、副秘书长(2022-至今)
中国化学会糖化学专业委员会委员(2019-至今)
中国生物化学与分子生物学学会糖复合物专业委员会青年工作委员会副主任委员(2019年-至今)
北京大学医学部新生专业班主任(2019-2021级)
发表论文
1. Kai-Meng Liu, Peng-Yu Wang, Zhen-Yan Guo, De-Cai Xiong*, Xian-Jin Qin, Miao Liu, Meng Liu, Wan-Ying Xue, and Xin-Shan Ye*, “Iterative Synthesis of 2-Deoxyoligosaccharides Enabled by Stereoselective Photoredox-catalyzed Glycosylation”, Angew. Chem. Int. Ed., 2022, 61, e202114726.
2. Xia Wu, Biao Wu, Chen-Fei Gao, Xin-Shan Ye, De-Cai Xiong*, “Additive-controlled synthesis of 1- and 2-deoxysugars from thioglycosides”, J. Carbohydr. Chem., 2021, 40(7-9), 479-500.
3. Yafei Cao+, Minmin Zhou+, Run-Ze Mao, You Zou, Feng Xia, Da-Ke Liu, Jianhui Liu, Qin Li, De-Cai Xiong*, Xin-Shan Ye*, “Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation”, Chem. Commun., 2021, 57, 10899-10902.
4. Miao Liu, Zhao-Xiang Luo, Tian Li, De-Cai Xiong*, Xin-Shan Ye*, “Electrochemical Trifluoromethylation of Glycals”, J. Org. Chem., 2021, 86(22), 16187-16194.
5. Zhao-Xiang Luo+, Miao Liu+, Tian Li, De-Cai Xiong*, Xin-Shan Ye*, “Electrochemical Bromination of Glycals”, Front. Chem., 2021, 9, 796690.
6. Miao Liu, Kai-Meng Liu, De-Cai Xiong,* Hanyu Zhang, Tian Li, Bo-Han Li, Xianjin Qin, Jinhe Bai, Xin-Shan Ye,* “Stereoselective Electro-2-Deoxyglycosylation from Glycals”, Angew. Chem. Int. Ed., 2020, 59, 15204-15208.
7. Miao Liu, Bo-Han Li, Tian Li, Xia Wu, Meng Liu, De-Cai Xiong,* Xin-Shan Ye,* "C-Glycosylation enabled by N-(glycosyloxy)acetamides”, Org. Biomol. Chem. 2020, 18, 3043-3046.
8. Bo-Han Li, Wenlong Yao, Hong Yang, Congying Wu, De-Cai Xiong,* Yuxin Yin,* Xin-Shan Ye*, "Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation”, Org. Chem. Front., 2020, 7, 1255–1259.
9. Zhen-Yan Guo, Jin-He Bai, Miao Liu, De-Cai Xiong*, Xin-Shan Ye*, “Advances in the Synthesis of C-Glycosides from Glycals”. Chin. J. Org. Chem., 2020, 40, 3094-3111.
10. Wanjun Yan, Wenming Li, De-Cai Xiong*, Xin-Shan Ye*, “Design, synthesis and evaluation of carbamate-containing sialyltransferase inhibitors”, J. Chin. Pharm. Sci. 2020, 29(1), 29-44.
11. Li Gefei, De-Cai Xiong*, Xin-Shan Ye, “Recent Progress and Development Trend of Synthetic Carbohydrate Vaccines”, Prog. Pharm. Sci. 2020, 44(7), 303-311.
12. Hanyu Zhang, Meng Liu, Xia Wu, Miao Liu, De-Cai Xiong*, Xin-Shan Ye*, “Photo-/Electro-Driven Carbohydrate-Based Reactions”, Prog. Chem. 2020, 32(11), 1804-1823.
13. Qiannan Zheng, Shengbiao Tang, De-Cai Xiong, Qin Li*, and Xin-Shan Ye*, “Carbocyclic Ring Closure of Aryl C-Glycosides Promoted by Fluoroboric Acid”, J. Org. Chem., 2020, 85(14), 9339–9346.
14. Zi-Pei Zhang, Wan-Ying Xue, Jian-Xing Hu, De-Cai Xiong, Yan-Fen Wu*, Xin-Shan Ye*, “Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors”, Chin. J. Nat. Med., 2020, 18(10), 729–737.
15. Jing-Jing Sui, De-Cai Xiong,* Xin-ShanYe,* “Copper-mediated O-arylation of lactols with aryl boronic acids”, Chin. Chem. Lett., 2019, 30, 1533-1537.
16. Da-Ke Liu, De-Cai Xiong, Xia Wu, Qin Li,* Xin-Shan Ye,* “Rapid glycosylation of 2′-benzoylphenyl glycosides promoted by TfOH”, Org. Chem. Front., 2019, 6, 2756–2759.
17. Yong-Shi Wang, Yong Wu, De-Cai Xiong, Xin-Shan Ye,* "Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent", Chin. J. Chem., 2019, 37, 42–48.
18. Miao Liu, Bo-Han Li, De-Cai Xiong,* Xin-Shan Ye,* "O-Glycosylation Enabled by Acetamidyl Glycosides", J. Org. Chem., 2018, 83(15), 8292–8303.
19. Gao-Lan Zhang, Meng-Man Wei, Chengcheng Song, Yu-Feng Ma, Xiu-Jing Zheng, De-Cai Xiong, Xin-Shan Ye*,“Chemical synthesis and biological evaluation of penta- to octa- saccharide fragments of Vi polysaccharide from Salmonella typhi”Org. Chem. Front., 2018, 5, 2179–2188.
20. Dong Wang, De-Cai Xiong*, Xin-Shan Ye*, “A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM5)”, Chin. Chem. Lett., 2018, 29, 1340-1342.
21. Shengbiao Tang, Qiannan Zheng, De-Cai Xiong,* Shende Jiang, Qin Li, Xin-Shan Ye*, “Stereocontrolled Synthesis of 2-Deoxy-C-Glycopyranosyl Arenes Using Glycals and Aromatic Amines”, Org. Lett. 2018, 20, 3079–3082.
22. Runze Mao, Lifeng Sun, Yong-Shi Wang, Min-Min Zhou, De-Cai Xiong, Qin Li*, and Xin-Shan Ye*, “N-9 Alkylation of purines via light-promoted and metal-free radical relay”, Chin. Chem. Lett., 2018, 29, 61-64.
23. Gao-Lan Zhang, Lin Yang, Jingjing Zhu, Mengman Wei, Wanjun Yan, De-Cai Xiong, Xin-Shan Ye*, “Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from Salmonella typhi”, Chem. Eur. J. 2017, 23, 10670-10677.
24. Yong Wu, De-Cai Xiong, Si-Cong Chen, Yong-Shi Wang, Xin-Shan Ye*, “Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units”, Nat. Commun. 2017, 8, 14851.
25. Yang Yu, De-Cai Xiong*, Run-Ze Mao, and Xin-Shan Ye*, “Visible Light Photoredox-Catalyzed O-Sialylation Using Thiosialoside Donors”, J. Org. Chem., 2016, 81(16), 7134–7138.
26. Lifeng Sun, Xiaowei Wu, De-Cai Xiong, Xin-Shan Ye*, “Stereoselective Koenigs–Knorr Glycosylation Catalyzed by Urea”, Angew. Chem. Int. Ed., 2016, 55, 8041-8044.
27. Yang Yu+, De-Cai Xiong+ and Xin-Shan Ye*, “2-Trifluoromethylthiolation of Glycals”, Org. Biomol. Chem. 2016, 14, 6403-6406.
28. Run-Ze Mao+, De-Cai Xiong+, Fan Guo, Qin Li, Jinyou Duan and Xin-Shan Ye*，“Light-driven highly efficient glycosylation reactions” Org. Chem. Front., 2016, 3, 737–743.
29. Chen-Fu Liu+, De-Cai Xiong+, Xin-Shan Ye*, “KOtBu-mediated aromatic O-glycosylation of 1,2-anhydrosugar and aryl boronic acid”, Tetrahedron Lett., 2016, 57, 1372-1374.
30. Shengbiao Tang, De-Cai Xiong, Shende Jiang*, and Xin-Shan Ye*， “Nitro- polyols via Pyridine Promoted C═C Cleavage of 2-Nitroglycals. Application to the Synthesis of (？)-Hyacinthacine A1”, Org. Lett. 2016, 18(3), 568–571.
31. Bang Wang, De-Cai Xiong*, and Xin-Shan Ye*, “Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis”, Org. Lett. 2015, 17(22), 5698–5701.
32. Run-Ze Mao+, Fan Guo+, De-Cai Xiong*, Qin Li, Jinyou Duan, and Xin-Shan Ye*, “Photoinduced C–S Bond Cleavage of Thioglycosides and Glycosylation”, Org. Lett. 2015, 17(22), 5606-5609.
33. Wenming Li, Youhong Niu, De-Cai Xiong, Xiaoping Cao, and Xin-Shan Ye*, “Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors”, J. Med. Chem. 2015, 58, 7972–7990.
34. Xuemei Yang+, De-Cai Xiong+, Chengcheng Song, Guihua Tai and Xin-Shan Ye*, “Synthesis of N-dialkylphosphoryl iminosugar derivatives and their immunosuppressive activities”, Org. Biomol. Chem. 2015, 13, 9364-9368.
35. Shao-Tao Bai+, De-Cai Xiong+, Youhong Niu, Yan-Fen Wu*, Xin-Shan Ye*, “Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2 inhibition activities”, Tetrahedron, 2015, 71, 4909-4919.
36. Yingguo Liu, Xiaxi Li, De-Cai Xiong, Binhan Yu, Xiaoping Pu*, and Xin-Shan Ye*, “Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents”, Eur. J. Med. Chem., 2015, 95, 313-323.
37. De-Cai Xiong+, Jingjing Zhu+, Ming-Jie Han, Hui-Xin Luo, Cong Wang, Yang Yu, Yuqian Ye, Guihua Tai, and Xin-Shan Ye*, “Rapid Probing of Sialylated Glycoproteinsin vitro and in vivo via Metabolic Oligosaccharide Engineering of Minimal Cyclopropene Reporter”, Org. Biomol. Chem. 2015, 13, 3911-3917.
38. De-Cai Xiong, An-Qi Yang, Yang Yu, and Xin-Shan Ye*, “2-Pyridyl Glycoside: An Alternative Glycosyl Donor in Preactivation Protocol”, Tetrahedron Lett., 2015, 56, 211-214.
39. Qi Qin, De-Cai Xiong, and Xin-Shan Ye*, “Additive-controlled Stereoselective Glycosylations of 2,3-Oxazolidinone Protected Glucosamine or Galactosamine Thioglycoside Donors with Phenols Based on Preactivation Protocol”, Carbohydr. Res., 2015, 403, 104-114.
40. De-Cai Xiong+, Yichuan Zhou+, Yuxin Cui, and Xin-Shan Ye*, “Synthesis of triazolyl-linked polysialic acids”, Tetrahedron 2014, 70, 9405-9412.
41. De-Cai Xiong, Chao Gao, Wenming Li, Yuan Wang, Qin Li, and Xin-Shan Ye*, “Synthesis of 2-Deoxy-C-glycosides via Lewis Acid-Mediated Rearrangement of 2,3-Anhydro-1-thiopyranosides”, Org. Chem. Front., 2014, 1, 798-806.
42. Chen-Fu Liu, De-Cai Xiong, and Xin-Shan Ye*, “‘Ring Opening？Ring Closure’ Strategy for the Synthesis of Aryl C-glycosides”, J. Org. Chem., 2014, 79(2), 4676–4686.
43. Xiaowei Wu, Fu-Yu Zhang, Jingjing Zhu, Chengcheng Song, De-Cai Xiong, Yifa Zhou, Yuxin Cui, and Xin-Shan Ye*, “N-Arylated-Lactam-Type Iminosugars as New Immunosuppressive Agents: Discovery, Optimization, and Biological Evaluation”, Chem. Asian. J. 2014, 9, 2260-2271.
44. Peng Peng, De-Cai Xiong, Xin-Shan Ye*, “Ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis”, Carbohydr. Res., 2014, 384, 1-8.
45. Fei-Fei Xu, Yue Wang, De-Cai Xiong, and Xin-Shan Ye*, “Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2”, J. Org. Chem., 2014, 79 (2), 797–802.
46. Ming-Jie Han, De-Cai Xiong, and Xin-Shan Ye*, “Enabling Wittig Reaction on Site-Specific Protein Modification”, Chem. Commun. 2012, 48(90), 11079-11081.
47. Yuan-Yuan Wang, De-Cai Xiong, Qin Li, Yuan Wang, Xin-Shan Ye*, “Syntheses of novel acarviosin analogs with anhydro or unsaturated sugar moieties”, Tetrahedron 2012, 68, 9355-9363.
48. Gen Li, De-Cai Xiong, Xin-Shan Ye*, “Synthesis of a-C-Glycosides by Samarium Diiodide Mediated Coupling of Glycosyl Pyridyl Sulfones with Alkenes”, Synlett 2011, 2410–2414.
49. Chao Gao, De-Cai Xiong, Yuan Wang and Xin-Shan Ye*, “Stereoselective synthesis of 2-deoxy-pyranosides via the Lewis acid-promoted rearrangement of 2,3-anhydrosugars”, J. Chin. Pharm. Sci. 2011, 20(2), 146-150.
50. De-Cai, Xiong, Li-He Zhang and Xin-Shan Ye*, “Bromodimethylsulfonium bromide-silver triflate: A new powerful promoter system for the activation of thioglycosides ”, Adv. Synth. Catal. 2008, 350(11-12), 1696-1700.
51. De-Cai Xiong, Li-He Zhang and Xin-Shan Ye*, “Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-glycosides”, Org. Lett. 2009, 11(8), 1709-1712.
请进入天然药物与仿生药物全国重点实验室网页
http://sklnbd.bjmu.edu.cn/k/e/action/ShowInfo.php?classid=100&id=244
