北京大学, 药学院药物化学系, 教授

教育经历

1995-08 至1998-07, 北京医科大学(现为北京大学医学部), 药物化学, 博士

1982-08 至1987-07, 北京医科大学, 药学, 学士

博士后工作经历

2000-04 至2002-09, 美国佐治亚大学(The University of Georgia, USA)

科研与学术工作经历

2008-07 至今, 北京大学医学部, 药学院，天然药物及仿生药物国家重点室, 教授

2002-09 至2008-06, 北京大学医学部, 药学院，天然药物及仿生药物国家重点室, 副教授

1998-08 至2000-04, 北京大学医学部, 药学院药物化学系, 副教授

1987-08 至1995-07, 北京医科大学, 药学院有机化学教研室, 讲师

部分代表性文章

1. Yufei Pan; Jing Guan; Yujing Gao; Yuejie Zhu; Huantong Li; Hua Guo; Qianyi He; Zhu Guan;ZhenjunYang ; Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit morepotent and longer-lasting anti-HCC effects, Molecular Therapy: Nucleic Acid,2023,32, 807-821.

2. Xiaotong Yu; Jing Yu; Hong Dai; Chenyun Deng; Xudong Sun; Sijie Long; Zhujun Jiang;Hongyan Jin; Zhu Guan; ZhenjunYang ; Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity, Theranostics, 2022, 19, 4552-4564.

3. Zhou, Xinyang; Pan, Yufei; Yu, Lijia; Wu, Jing; Li, Zheng; Li, Huantong; Guan, Zhu; Tang, Xinjing; Yang, Zhenjun ; Feasibility of cRGD conjugation at 5'-antisense strand of siRNA by phosphodiester linkage extension, Molecular Therapy - Nucleic Acids, 2021, 25(2), 603-612.

4. Ma, Yuan; Zhao, Wenting; Li, Yiding; Pan, Yufei; Wang, Shuhe; Zhu, Yuejie; Kong,Lingxuan; Guan, Zhu; Wang, Jiancheng; Zhang, Lihe; Yang, Zhenjun; Structural optimization and additional targets identification of antisense oligonucleotide G3139 encapsulated in a neutral cytidinyl-lipid combined with a cationic lipid in vitro and in vivo, Biomaterials, 2019, 197, 182-193.

5. Ma, Yuan; Zhu, Yuejie; Wang, Chao; Pan, Delin; Liu, Shuang; Yang, Mengyi; Xiao,Zhangping; Yang, Xiantao; Zhao, Wenting; Zhou, Xinyang; Li, Yiding; Pan, Yufei; Sun, Jing; Wang,Shuhe; Guan, Zhu; Zhang, Lihe; Yang, Zhenjun; Annealing novel nucleobase-lipids with oligonucleotides or plasmid DNA based on H-bonding or pi-pi interaction: Assemblies and transfections, Biomaterials, 2018,178,147-157.