Yangtze river scholars Distinguished Professor
Research Areas
Organic Chemistry
Education & Positions
University of Science and Technology of China (USTC), B.S., 1994
Massachusetts Institute of Technology, Ph.D., 2000
B.S. Organic Chemistry, Shandong University, China, 1995-1999
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Ph D (Supervisor: Professor Shengming Ma), 1999-2004
Max Planck Institute für Kohlenforschung (MPI) Mülheim an der Ruhr, Germany, Postdoctoral Fellow (Supervisor: Professor Manfred T. Reetz), Humboldt Fellowship, 2004-2006
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Associate Professor 2007-2010, Professor 2010- Vice Director of the State Key Laboratory of Natural and Biomimetic Drugs, 2012- Yangtze river scholars Distinguished Professor, 2015-
Faculty Accolades
2017 The National Young and Middle-aged Expert with Remarkable Contributions (by the Ministry of Human Resources and Social Security of China)
2017 Participant of the New Century National Talents Project (State Level)
2017 The Chinese Chemical Society-BASF Innovation Award
2017 Bayer Investigator Award
2016 The National Young and Middle-aged Leading Science and Technology Innovation Talents (by the National Ministry of Science and Technology)
2015 Yangtze river scholars Distinguished Professor
2015 Fellow of the Royal Society of Chemistry
2014 Roche Chinese Young Investigator Award
2014 Guest Professor, University of Münster
2013 The National Science Fund for Distinguished Young Scholars
2013 The Chinese Homogenous Catalysis Young Chemist Award
2013 Thieme Chemistry Journal Award
2013 Asian Core Program Lectureship Award (the Asian Cutting-Edge Organic Chemistry programs), Japan and Thailand, and Singapore, 2012
2012 National Youth Top-notch Talents
2011 “Distinguished Lectureship Award”, the Asian Symposium of Annual Meeting of Chemical Society of Japan
2010 CAPA Distinguished Faculty Award from Chinese-American Chemistry & Chemical Biology Professors Association (CAPA)
2010 The Chinese Pharmaceutical Association Young Investigator Awards
2010 The Chinese Chemical Society Young Chemist Award
2008 "New Century Excellent Talents in University Award" from Chinese Ministry of Education
Research Interests
Our research efforts are focused on: 1) To develop green and efficient synthetic methodologies towards the natural products and bioactive compounds modification, as well as the drug discovery; 2) To develop novel methodologies on Aerobic oxidation, Oxygenation, Nitrogenation, and Halogenation reactions; 3) To develop novel methodologies by the first-row transition metal catalysis and the inert chemical bonds activation.
Grants and Fundings
The National Science Fund for Distinguished Young Scholars
National Program on Key Basic Research Project of China (973 Program)
the State Key Program of National Natural Science of China
Principal Investigator
Publications
1. Yuchao Zhu, Kaimeng Hunag, Jun Pan, Xu Qiu, Xiao Luo, Qixue Qin, Jialiang Wei, Xiaojin Wen, Lizhi Zhang, and Ning Jiao*, Silver-Catalyzed Remote Csp3-H Functionalization of Aliphatic Alcohols, Nature Commun. 2018, NCOMMS-18-06810B .
2. Jun Pan, Xinyao Li, Fengguirong Lin, Jianzhong Liu, Ning Jiao*, Chemoselective Nitrosylation of Anilines and Alkynes via Fragmentary or Complete ‘NO’ Incorporation, Chem 2018, 2 , doi: 10.1016/j.chempr.2018.03.008.
3. Xinwei Li, Fengguirong Lin, Kaimeng Huang, Jialiang Wei, Xinyao Li, Xiaoyang Wang, Xiaoyu Geng, and Ning Jiao*, Selective α-Oxyamination and Hydroxylation of Aliphatic Amides, Angew. Chem. Int. Ed. 2017, 56 , 12307-12311.
4. Jianzhong Liu,？ Xiaojin Wen,？ Chong Qin,？ (？These two authors contributed equally to this work), Xinyao Li, Xiao Luo, Ao Sun, Bencong Zhu, Song Song,* and Ning Jiao*, Oxygenation of Simple Olefins via Selective Allylic C-C Bond Cleavage: A Direct Approach to Cinnamyl Aldehydes, Angew. Chem. Int. Ed. 2017, 56 , 11940-11944.
5. Yu-Feng Liang, and Ning Jiao*, Oxygenation via C？H/C？C Bond Activation with Molecular Oxygen, Acc. Chem. Res. 2017, 50 , 1640-1653 (invited).
6. Song Song,* Yiqun Zhang, Adeli Yeerlan, Bencong Zhu, Jianzhong Liu, and Ning Jiao*, Cs2CO3-Catalyzed Aerobic Oxidative Cross Dehydrogenative Coupling Reaction of Thiols with Phosphonates and Arenes, Angew. Chem. Int. Ed. 2017, 56 , 2487-2491.
7. Tao Shen, Yiqun Zhang, Yu-Feng Liang, Ning Jiao*, Direct Tryptophols Synthesis from 2-Vinylanilines and Alkynes via C≡C Triple Bond Cleavage and Dioxygen Activation, J. Am. Chem. Soc. 2016, 138 (40), 13147-13150.
8. Yu-Feng Liang,？ Xinyao Li,？(？These two authors contributed equally to this work), Xiaoyang Wang, Miancheng Zou, Conghui Tang, Yujie Liang, Song Song, Ning Jiao*, Conversion of Simple Cyclohexanones into Catechols, J. Am. Chem. Soc. 2016, 138(37) , 12271–12277.
9. Yujie Liang, and Ning Jiao*, Cationic Cobalt(III)-Catalyzed Direct Indole Synthesis: The Regioselective Intermolecular Cyclization of N-nitrosoanilines and Alkynes, Angew. Chem. Int. Ed. 2016, 55 , 4035-4039.
10. Chong Qin,？ Yijin Su,？ (？These two authors contributed equally to this work), Tao Shen, Xiaodong Shi* and Ning Jiao*, Split A Substrate to Three Parts and Reassemble: Au-Catalyzed Nitrogenation of Alkynes via C-C and C≡C Bond Cleavages, Angew. Chem. Int. Ed. 2016, 55 , 350-354.
11. Xinyao Li, Xinwei Li, and Ning Jiao*, Rh-Catalyzed Quinolin-2(1H)-ones Construction via C-H Bond Activation of Simple Anilines with CO and Alkynes, J. Am. Chem. Soc. 2015, 137, 9246-9249.
12. Haihui Peng, Novruz G. Akhmedov, Yu-Feng Liang, Ning Jiao*, and Xiaodong Shi*, Synergistic Gold and Iron Dual Catalysis: Preferred Radical Addition toward Vinyl？Gold Intermediate over Alkene, J. Am. Chem. Soc. 2015, 137 , 8912-8915.
13. Xiang Sun,？ Xinyao Li,？ (？These two authors contributed equally to this work) Song Song, Yuchao Zhu, Yu-Feng Liang and Ning Jiao*, Mn-catalyzed Highly Efficient Aerobic Oxidative Hydroxyazi-dation of Olefins: A Direct Approach to β-Azido Alcohols, J. Am. Chem. Soc. 2015, 137 , 6059-6066.
14. Xiaoqiang Huang, Xinyao Li, Miancheng Zou, Song Song, Conghui Tang, Yizhi Yuan, and Ning Jiao*, From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)-C(alkyl) Bond Cleavage: Aerobic Oxidation and Oxygenation with Air, J. Am. Chem. Soc. 2014, 136 , 14858-14865.
15. Feng Chen,？ Xiaoqiang Huang,？ Xinyao Li,？ (？These two authors contributed equally to this work) Tao Shen, Miancheng Zou, and Ning Jiao*, Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions, Angew. Chem. Int. Ed. 2014, 53, 10495-10499.
16. Feng Chen, Teng Wang, and Ning Jiao,* Recent Advances in Transition-Metal-Catalyzed Functionalization of Unstrained Carbon-Carbon Bonds, Chem. Rev. 2014, 114 (17), pp 8613–8661.(Invited Contribution).
17. Conghui Tang and Ning Jiao*, Copper-Catalyzed Aerobic Oxidative C？C bond Cleavage for C？N Bond Formation: From Ketones to Amides, Angew. Chem. Int. Ed. 2014, 53 , 6528-6532. (Hot Paper).
18. Teng Wang, and Ning Jiao*, Direct Approaches to Nitriles via Highly Efficient Nitrogenation Strategy through C–H or C–C Bond Cleavage, Acc. Chem. Res. 2014, 47 , 1137-1145.(Invited Contribution).
19. Yu-Feng Liang and Ning Jiao*, Highly Efficient C？H Hydroxylation of Carbonyl Compounds with Oxygen under Mild Conditions, Angew. Chem. Int. Ed. 2014, 53 , 548-552.
20. Chun Zhang, Peng Feng and Ning Jiao*, Cu-Catalyzed Esterification Reaction via Aerobic Oxygenation and C-C Bond Cleavage: An Approach to α -Ketoesters, J. Am. Chem. Soc. 2013, 135 , 15257–15262.
21. Teng Wang and Ning Jiao*, TEMPO-catalyzed Aerobic Oxygenation and Nitrogenation of Olefins via C="C" Double Bond Cleavage, J. Am. Chem. Soc. 2013, 135 , 11692-11695.
22. Yijin Su,？ Xiang Sun,？(？These two authors contributed equally to this work)Guolin Wu, and Ning Jiao*, Catalyst-controlled Highly Selective Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones and Diketones, Angew. Chem. Int. Ed . 2013, 52 , 9808-9812 (10.1021/anie.201303917).
23. Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang and Ning Jiao*, Highly Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides, Angew. Chem. Int. Ed. 2013, 52 , 7850-7854. (Hot Paper).
24. Tao Shen, Teng Wang, Chong Qin, and Ning Jiao*, Silver-catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles via C-C Triple Bond Cleavage, Angew. Chem. Int. Ed. 2013, 52 , 6677-6680. (Hot Paper) (Highlighted by Synfact (2013, 9(9), 0949).
25. Yuepeng Yan, Peng Feng, Qing-Zhong Zheng, Yu-Feng Liang,Jingfen Lu, and Ning Jiao*, PdCl2 and N -Hydroxyphthalimide Co-catalyzed Csp2？H Hydroxylation by Dioxygen Activation, Angew. Chem. Int. Ed. 2013, 52 , 5827-5831.
26. Conghui Tang and Ning Jiao*, Copper-catalyzed C-H Azidation of Anilines under Mild Conditions, J. Am. Chem. Soc. 2012, 134 , 18924-18927.(Highlighted by Synform (2013, 02, A21) and Synfact (2013, 9(2), 0207), Highlighted by Angew. Chem. Int. Ed. 10.1002/anie.201302015 )
27. Zejun Xu,？Chun Zhang,？(？These two authors contributed equally to this work)and Ning Jiao*, Synthesis of Oxazoles through Copper-Mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines, Angew. Chem. Int. Ed. 2012, 51 , 11367–11370(Hot Paper) .
28. Teng Wang, Wang Zhou, Hang Yin, Jun-An Ma, and Ning Jiao*, Iron-Facilitated Oxidative Dehydrogenative C-O Bond Formation via Propargyl Csp3–H Functionalization. Angew. Chem. Int. Ed. 2012, 51 , 10823-10826.
29. Chong Qin, Tao Shen, Conghui Tang, and Ning Jiao*, FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines, Angew. Chem. Int. Ed. 2012, 51 , 6971-6975 (Hot Paper).
30. Shengtao Ding, and Ning Jiao*, N,N-Dimethylformamide: A Multipurpose Building Block, Angew. Chem. Int. Ed. 2012, 51 , 9226-9237. (review, invited contribution).
31. Chun Zhang, Chonghui Tang, and Ning Jiao*, Recent Advances in Copper-catalyzed Dehydrogenative Functionalization via Single Electron Transfer (SET) Process. Chem. Soc. Rev. 2012, 41 , 3464-3484.
32. Zhuangzhi Shi, Chun Zhang, Chonghui Tang, and Ning Jiao*, Recent Advances in Transition-metal Catalyzed Reactions Using Molecular Oxygen as the Oxidant. Chem. Soc. Rev. 2012, 41 , 3381-3430.
33. Chong Qin, Wang Zhou, Feng Chen, Yang Ou, and Ning Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules, Angew. Chem. Int. Ed. 2011, 50 , 12595-12599.
34. Feng Chen, Chong Qin, Yuxin Cui, and Ning Jiao*, Implanting Nitrogen into Hydrocarbon Molecules via C-H/C-C Bonds Cleavage: The Direct Approach to Tetrazoles. Angew. Chem. Int. Ed. 2011, 50 , 11487-11491. (Highlighted by Synfacts ( Synfacts , 2012, 8 , 0144.).
35. Chun Zhang, Zejun Xu, Liangren Zhang, and Ning Jiao*, Copper-catalyzed Aerobic Oxidative Coupling of Aryl Acetaldehydes with Anilines Leading to α-Ketoamides. Angew. Chem. Int. Ed. 2011, 50 , 11088-11092. (VIP articles, Frontispiece Paper, Highlighted by ChemCatChem ( ChemCatChem , 2012, 4 , 175-176)
36. Shengtao Ding, and Ning Jiao*, The Direct Transformation of DMF (N,N-Dimethylformamide) to -CN: Pd-catalyzed Cyanation of Heteroarenes via C-H Functionalization. J. Am. Chem. Soc. 2011, 133 (32), 12374-12377. (Highlighted by Org. Process Res. Dev. 2011, 15 , 1216–1221).
37. Chong Qin, and Ning Jiao*, Iron-Facilitated Direct Oxidative C？H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. J. Am. Chem. Soc. 2010, 132 , 15893-15895. (Most accessed articles, Highlighted by Synfacts ( Synfacts , 2011, 2 , 203))
38. Chun Zhang, and Ning Jiao*, Cu-catalyzed Aerobic Oxidative Dehydrogenative Coupling of Anilines Leading to Aromatic Azo Compounds using Dioxygen as Oxidant. Angew. Chem. Int. Ed. 2010, 49 , 6174-6177. (Most accessed articles)
39. Zhuangzhi Shi, Bo Zhang, Yuxin Cui, and Ning Jiao*, Palladium-Catalyzed Ring-expansion Reaction of Indoles with Alkynes: From Indoles to Tetrahydroquinoline Derivatives Under Mild Conditions. Angew. Chem. Int. Ed. 2010, 49 , 4036-4041. (Frontispiece Paper, Most accessed articles)
40. Chun Zhang, and Ning Jiao*, Dioxygen Activation at Ambient Conditions: Cu-catalyzed Oxidative Amidation-Diketonization of Terminal Alkynes Leading to α-Ketoamides. J. Am. Chem. Soc. 2010, 132 , 28-29. (Highlighted by Org. Chem. )
41. Zhuangzhi Shi, Shengtao Ding, Yuxin Cui, and Ning Jiao*, Pd-catalyzed Oxidative Cycloaromatization of Biaryls with Alkynes Using Dioxygen as Oxidant. Angew. Chem. Int. Ed. 2009, 48 , 7895-7898.
42. Wang Zhou, Liangren Zhang, and Ning Jiao*, Direct Transformation of Methyl Aromatics to Aryl Nitriles at Room Temperature. Angew. Chem. Int. Ed. 2009, 48 , 7094-7097. (Hot Paper) (Highlighted by “ Synform, 2009 , A71”, “ Org. Chem. Highlights ” (2010, September 27), and “Nature China ”.
43. Zhuangzhi Shi, Chun Zhang, Si Li, Delin Pan, Sengtao Ding, Yuxin Cui, and Ning Jiao*, Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant. Angew. Chem. Int. Ed. 2009, 48 , 4572-4576.
