Research Areas
Medicinal Chemistry and Chemical Biology
Education & Positions
University of Science and Technology of China (USTC), B.S., 1994
Massachusetts Institute of Technology, Ph.D., 2000
Sichuan University, Undergraduate Student, BS, 2000-2004
Sichuan University, Graduated Student, PhD, 2004-2009
University of Illinois at Urbana-Champaign, USA, Visiting Scholar, 2007-2008
Peking University, Postdoc 2009-2011
Peking University, Assistant Professor 2011-2014
Peking University, Associate Professor 2014-
Research Interests
Molecular Probe and drug design
Grants and Fundings
National Natural Science Foundation of China (21172003)
Publications
1. Tongliang Zhou, Junda Wang, Jiamin Xu, Cangxin Zheng, Yan Niu, Chao Wang, Fengrong Xu, Lan Yuan, Xin Zhao,* Lei Liang,* Ping Xu,* A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging. Analytical Chemistry 2020, https://doi.org/10.1021/acs.analchem.9b05435.
2. Hongyue Li, Dandan Xi, Yan Niu, Chao Wang, Fengrong Xu, Lei Liang,* Ping Xu,* Design, synthesis and biological evaluation of cobalt(II)-Schi？ base complexes as ATP-noncompetitive MEK1 inhibitors. Journal of Inorganic Biochemistry 2019, 195 , 174-181.
3. Tongliang Zhou, Lingfei Yang, Lei Liang,* Hui Liu, Yuanjun Zhu,* Mengyang Shui, Lan Yuan,* Fengrong Xu, Yan Niu, Chao Wang, Ping Xu,* Rational Design of a Near-infrared Fluorescent Probe Based on Pyridazinone Scaffold. Eur. J. Org. Chem ., 2017, 3274-3281.
4. Yuanjun Zhu, Tongliang Zhou, Lingfei Yang, Lan Yuan, Lei Liang,* Ping Xu,* Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochem & Biophy Res. Comm., 2017 , 486, 904-908.
5. Hongyue Li, Tongliang Zhou, Hui Liu, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Discovery of a cobalt complex with high MEK1 binding affinity. Bioorg. Med. Chem. Lett., 2017, 27 , 2221-2224.
6. Tongliang Zhou, Yuanbo Cai, Lei Liang,* Lingfei Yang, Fengrong Xu, Yan Niu, Chao Wang, Junlong Zhang,* Ping Xu,* Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes. Bioorg. Med. Chem. Lett., 2016, 26 , 5780-5784.
7. Lingfei Yang, Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Jun-Long Zhang, Ping Xu,* Lan Yuan,* and Lei Liang,* Rational design of fluorescent phthalazinone derivatives for one- and two-photon imaging. Chem. Eur. J., 2016, 22 , 12363-12370.
8. Lingfei Yang, Wei Wang, Qi Sun, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorg. Med. Chem. Lett., 2016, 26 , 2801-2805.
9. Wei Wang, Lei Liang,* Fengrong Xu, Wenjie Huang, Yan Niu, Qi Sun, Ping Xu,* Ruthenium-Catalyzed Switchable N–H/C–H Alkenylation of 6-Phenyl(dihydro)pyridazinones with Alkynes. Eur. J. Org. Chem . 2014, 6863–6867.
10. Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu*, Ping Xu*, Rational Design, Green Synthesis, and Initial Evaluation of a Series of Full-Color Tunable Fluorescent Dyes Enabled by the Copper-Catalyzed N-Arylation of 6-Phenyl Pyridazinones and Their Application in Cell Imaging. Chem. Eur. J., 2013, 19 , 13774-13782.
11. Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation. Org. Lett ., 2013, 15 , 2770-2773.
12. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, A Copper-Catalyzed Aerobic Cascade Dehydrogenative Dehalogenative Reaction. Adv. Syn&Cat. , 2013, 355 , 1284-1290.
13. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Copper-Catalyzed Aerobic Dehydrogenation of C–C to C="C" Bonds in the Synthesis of Pyridazinones. Eur. J. Org. Chem ., 2013, 6130–6136.
