Research Areas
Nucleic Acid Chemical Biology and Nucleic Acid Drugs
Optical Nanoprobes for Cancer Detection and Imaging
Education & Positions
Shandong University, B.S., 1997 Technical Institute of Physics and Chemistry, the Chinese Academy of Sciences, Ph.D., 2002 University of Pennsylvania, Postdoctoral Fellow and Research Associate, 2003-2009 Peking University, Associate Professor 2009-2016, Professor 2016-
Faculty Accolades
YiLing Biomedical Award, Chinese Pharmaceutical Association, 2017
Zhongwai Award，2017
Changjiang Young Scholar, Ministry of Education of the People Republic of China, 2015
Excellent Young Scientist program of National Natural Science Foundation of China (NSFC), 2014
LvYe Award, 2014
Servier Young Investigator Awards in Medicinal Chemistry, 2013
Research Interests
Our research program spans a broad range of chemical biology, nucleic acid chemistry and medicine, as well as nanoprobes for cancer detection and imaging. We focused on developing modified intelligent functional oligonucleotides and their delivery system to spatiotemporally regulate their activities. In addition, we also designed and developed now new fluorescent oligonucleotide probes for SNA nucleic acid detection and new optical nanoprobes for cancer detection and imaging. Our goal is to solve the off-target effect of nucleic acid drugs and develop targeting detection system in precision medicine.
Grants and fundings
Ministry of Science and Technology of China, Major Projects for New Drug Development (NO. 2017ZX09303013)
Innovative Team project of National Natural Science Foundation of China, (PI, 2018)
Innovative Team project of Ministry of Science and Technology of China, (PI, 2017)
National Natural Science Foundation of China (NO. 21672015)
International Exchange Project of China- South Korea (NO. 21511140281)
National Natural Science Foundation of China, Excellent Young Scholar Program (NO. 21422201)
National Natural Science Foundation of China (NO. 21372018)
Ministry of Science and Technology of China, “973” program (PI, NO. 2012CB720600)
Ministry of Science and Technology of China, “973” program (PI, NO. 2013CB933800)
Innovative Team project of Ministry of Education of China (PI, 2013)
Publications
1. Jiali Yang, Changmai Chen, Xinjing Tang* Cholesterol-modified Caged siRNAs for Photoregulating Exogenous and Endogenous Gene Expression, Bioconjugate Chem . 2018, DOI: 10.1021/acs.bioconjchem.8b00080
2. Changmai Chen, Zhenjun Yang, Xinjing Tang*, Chemical Modifications of Nucleic Acid Drugs and Their Delivery Systems for Gene-based Therapy, Med Res. Rev. 2018, 38:829–869 (front cover)
3. Liangliang Zhang, Changmai Chen, Xinli Fan and Xinjing Tang* Photomodulating Gene expression Using Caged siRNAs with Single Aptamer Modification, ChemBioChem , 2018, DOI: 10.1002/cbic.201700623
4. Amu Gubu, Long Li, Xiaoyun Zhang, Seonghyun Lee, Mengke Feng, Qiang Li, Xiaoguang Lei, Kyubong Jo, Xinjing Tang* Bioorthogonal metabolic cellular DNA labelling using vinyl thioether modified thymidine and o-quinolinone quinone methide, Chem. Eur. J. 2018, 24, 5895-5900
5. Liangliang Zhang, Duanwei Liang, Changmai Chen, Yuan Wang, Gubu Amu, Jiali Yang, Lijia Yu, Ivan J. Dmochowski, Xinjing Tang* Circular siRNAs for reducing off-target effects and enhancing long-term gene silencing in cells and mice, Mol. Ther. Nucl. Acids , 2018, 10, 237-244
6. Liangliang Zhang, Duanwei Liang, Yuan Wang, Dong Li, Jinhao Zhang, Li Wu, Mengke Feng, Fan Yi, Luzheng Xu, Liandi Lei, Quan Du and XinJing Tang* Caged circular siRNAs for photomodulation of gene expression in cells and mice, Chem. Sci ., 2018, 9, 44 – 51 (front cover)
7. Xueli Zhang, Xinjing Tang*，Nucleic Acid Chemical Biology， Image Science and Photochemistry , 2017, 15(04), 477-493
8. Yating Xiao？, Qingju Liu？, Xinjing Tang, Zhenjun Yang, Li Wu*, and Yujian He* Mirror-image Thymidine Discriminates against Incorporation of dNTP into DNA and Repairs Itself by DNA Polymerases， Bioconjugate Chem ., 2017, 28 (8), 2125–2134
9. Qingqing Jin, Amu Gubu, Xiuxian Chen and Xinjing Tang*. A Photochemical Avenue to Photoluminescent N-Dots and their Upconversion Cell Imaging, Sci. Rep . , 2017, 7, 1793.
10. Jiali Yang, Lijia Yu, Liangliang Zhang, xingsu Long, Yuzhuo Ji, and Xinjing Tang*, Synthesis and evaluation of caged sirna with terminal single vitamin E modification. Curr. Protoc. Nucleic Acid Chem . 67:16.6.1-16.6.22. doi: 10.1002/cpnc.16
11. Jinxing Liu, Mengke Feng, Duanwei Liang, Jiali Yang, and Xinjing* Tang Vitamin E Labelled Polyethyleneimine for in vitro and in vivo Gene Delivery, Biomacromolecules , 2016, 17(10), 3153–3161
12. Zhisheng Wu, Duanwei Liang and Xinjing Tang* Visualizing Hydrogen Sulfide in Mitochondria and Lysosome of Living Cells and in Tumor of Living Mice with Positively Charged Fluorescent Chemosensors, Anal Chem ., 2016, 88(18), 9213–9218
13. Zhixuan Wang, Xiaojing Pei, Na Li, Xinjing Tang* Phosphate-perylene modified G-quadruplex probes for the detection of Pb2+ by fluorescence anisotropy, J. Mater. Chem. B , 2016, 4, 4330 - 4336
14. Gulnur Imincan, Fen Pei, Lijia Yu, Hongwei Jin, Liangren Zhang, Xiaoda Yang, Lihe Zhang, XinJing Tang* Microenvironmental Effect of 2￠-O-(1-Pyrenylmethyl)uridine Modified Fluorescent Oligonucleotide Probes on Sensitive and Selective Detection of Target RNA, Anal. Chem ., 2016, 88, 4448–4455
15. Zhisheng Wu, Mengke Feng, Xiuxian Chen, Xinjing Tang*, N-dots as photoluminescent probe for rapid and selective detection of Hg2+ and Ag+ in aqueous solution. J Mater. Chem. B , 2016, 4, 2086-2089
16. Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu, Xinjing Tang* Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification, Angew Chem Intl Ed . 2016, 55, 2152-2156
17. Pengfei Li, Hongyan He, Zhixuan Wang, Mengke Feng, Hongwei Jin, Yun Wu, Liangren Zhang and Lihe Zhang, Xinjing Tang, Sensitive detection of single nucleotide mutation in BRAF mutation site (V600E) of human melanoma using phosphate-pyrene-labelled DNA probes Anal. Chem ., 2016, 88, 883-889
18. Zhisheng Wu, Xinjing Tang*, Visualizing Fluoride ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes Anal. Chem. , 2015, 87, 8613-8617.
19. Junzhou Wu, Duanwei Liang, Qingqing Jin, Jie Liu, Meiling Zheng Xuanming Duan, and Xinjing Tang*, Bioorthogonal SERS Nanoprobes for Mulitplex Spectroscopic Detection and Tumor Cell Targeting and Tissue Imaging, Chem. Eur. J ., 2015, 21,12914-12918.
20. Li Wu, Yujian He*, Xinjing Tang*, Photoregulating RNA digestion using azobenzene linked dumbbell antisense oligodeoxynucleotides, Bioconjugate Chem. 2015, 26, 1070？1079
21. Jingjing Sun, Xinjing Tang*, Photouncaged Sequence-specific Interstrand DNA Cross-Linking with Photolabile 4-oxo-enalmodified Oligonucleotides Sci. Rep . 2015, 5:10473
22. Wengang Ji, Yuzhuo Ji, Qingqing jin, Qingxiao Tong, Xinjing Tang*, Heavy Atom Quenched Coumarin Probes for Sensitive and Selective Detection of Biothiols in Living Cells, Analyst , 2015，140, 4379 - 4383
23. Li Wu, Xinjing Tang*, Synthesis of site-specifically phosphate-caged siRNA, Curr. Protoc. Nucleic Acid Chem , 2015, 61:6.12.1-6.12.15.
24. Li Wu, Ya Wu, Hongwei Jin, Liangren Zhang, Yujian He*, and Xinjing Tang*, Photoswitching property of hairpin ODNs with azobenzene derivatives in the loop, MedChemComm , 2015, 6, 461
25. Long Li, Yuzhuo, Xinjing Tang*, Quaternary Ammonium Promoted Ultra Selective and Sensitive Fluorescence Detection of Fluoride Ion in Water and Living Cells, Anal. Chem ., 2014, 86, 10006-10009
26. Xiuxian Chen, Qingqing Jin, Lizhu Wu, ChenHo Tung, Xinjing Tang*, Synthesis and Unique Photoluminescence Properties of Novel Nitrogen-rich Quantum dots and Their Applications, Angew Chem. Int. Ed ., 2014, 53, 12542-12547
27. Li Wu, Fen Pei, Jinhao Zhang, Junzhou Wu, Mengke Feng, Yuan Wang, Hongwei Jin, Liangren Zhang, Xinjing Tang* Synthesis of Site-specifically Phosphate-caged siRNAs and Evaluation of their RNAi Activity and Stability, Chem. Eur. J. , 2014, 20, 12114-12122
28. Zhisheng Wu, Yongliang Feng, Bin Geng, Junyi Liu and Xinjing Tang* Fluorogenic sensing of H2S in blood and living cells via reduction of aromatic dialkylamino N-oxide, RSC Adv ., 2014, 4, 30398–30401
29. Bifeng Chen, Peng Wang, Qingqing Jin and Xinjing Tang* Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells, Org. Biomol. Chem ., 2014, 12, 5629–5633
30. Pengfei Li, Jingjing Sun, Xiaogai Yang and XinJing Tang* Design, synthesis and properties of artificial nucleic acids from (R)-4-amino-butane-1,3-diol, Org. Biomol. Chem ., 2014, 12, 2263-2272
31. Junzhou Wu, Jie Wang and XinJing Tang* Synthesis of photolabile dUTP analogues and their enzymatic incorporation for DNA labeling, Sci. China Chem. 2014, 57, 322-328
32. Xinjing Tang,* Jinhao Zhang, Jingjing Sun, Yuan Wang, Junzhou Wu and Lihe Zhang, Caged nucleotides/nucleosides and their photochemical biology, Org. Biomol. Chem. , 2013, 11, 7814–7824
33. Zhen Wang, Peng Wang, Xinjing Tang*, Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release. ChemPlusChem , 2013, 78, 1273–1281
34. Junzhou Wu, XinJing Tang* Synthesis and enzymatic incorporation of photolabile dUTP analogues into DNA and their applications for DNA labeling, Bioorg. Med. Chem. , 2013, 21, 6205-6211
35. Zhen Wang, Lili Yu, Cong Lv, Peng Wang, Yedong Chen, Xinjing Tang* Photoresponsive Cross-linked Polymeric Particles for Phototriggered Burst Release, Photochem. Photobiol . 2013, 89, 552-559
36. Li Wu, Yuan Wang, Junzhou Wu, Jie Wang, Xinjing Tang* Caged Circular Antisense Oligonucleotides for Photomodulation of RNA Digestion and Gene Expression in Cells. Nucleic Acids Res ., 2013, 41. 677-686
37. Bifeng Chen, Wei Li, Cong Lv, Manman Zhao, Hongwei Jin, Hongfang Jin, Junbao Du, Liangren Zhang, Xinjing Tang* Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac Tissues Analyst , 2013, 138, 946-951.
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