Member of the Chinese Academy of Sciences, Professor
Research Areas
Chemical Biology; Organic Chemistry
Education & Positions
Massachusetts Institute of Technology, Ph.D., 2000
University Education:
1964-1967 Graduate School, Beijing Medical College, China. Major in Medicinal Chemistry, MS
1954-1958 Department of Pharmacy, Beijing Medical College, China. BA
Professional Experience:
2006-date President, Academic Committee of State Key Laboratory of Natural & Biomimetic Drugs, Peking University
2000-date Professor of Medicinal Chemistry, Peking University
1992-2006 Director, State Key Laboratory of Natural and Biomimetic Drugs, Peking University
1998-2006 Director, Chemistry Department, National Natural Science Foundation of China
1986-2000 Dean, Professor of Medicinal Chemistry, School of Pharmaceutical Sciences, Beijing Medical University
1983-1986 Associate Professor, School of Pharmaceutical Sciences, Beijing Medical University
1981-1983 Research Associate, Department of Chemistry, University of Virginia, USA
1967-1981 Lecturer, Department of Pharmacy, Beijing Medical College
1958-1964 Assistant, Department of Pharmacy, Beijing Medical College
Faculty Accolades
2013 "CAI Yuanpei Award", the highest honor for teachers of Peking University
2012 "Beijing Outstanding people’s Teacher" the highest honor for teachers in Beijing
2009 Nagai-Hisamitsu Outstanding Science Award, Asia Pharmaceutical Association, Kyoto, Japan
2004 Natural Science Award, Second Prize, Ministry of Science and Technology, China
2002 Science and Technology Award, Second Prize, awarded by The Ministry of Education, China
2000 Millennium Pharmaceutical Scientist Award, FIP, San Francisco, USA
1999 He-Liang-He-Li Prize
1998 Science and Technology Award, First Prize, awarded by The Ministry of Education, China
1996 Science and Technology Award, Second Prize, awarded by The Ministry of Education, China
1964 National Award for Scientific Research Excellence, State Commission Science & Technology, China
Research Interests
Chemistry of Nucleoside, Nucleotide and Oligonucleotide; Anticancer and Antiviral Drug; Natural Product.
Publications
Over 350 in refereed journals. Selected Publications:
1. Identifying glyceraldehyde 3-phosphate dehydrogenase as a cyclic adenosine diphosphoribose binding protein by photoaffinity protein-ligand labeling approach, KH Zhang, W Sun, LH Huang, KY Zhu, F Pei, LC Zhu, Q Wang, YY Lu, HM Zhang, HW Jin, LH Zhang*, LR Zhang*, JB Yue*, J. Am. Chem. Soc. , 2017, 139(1), 156-170.
2. Generation of influenza A viruses as live but replication-incompetent virus vaccines, LL Si, H Xu, XY Zhou, ZW Zhang, ZY Tian, Y Wang, YM Wu, B Zhang, ZL Niu, CL Zhang, G Fu, SL Xiao, Q Xia, LH Zhang, DM Zhou*, Science , 2016, 354 (6316), 1170-1173
3. The effects of conformational alteration induced by D-/L-isonucleoside incorporation in siRNA on their stability in serum and silencing activity, Y Huang, Z Chen, Y Chen, H Zhang, YC Zhang, YL Zhao, ZJ Yang*, LH Zhang*, Bioconjugate Chem. , 2013, 24 , 951-959.
4. A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge, N Qi, K Jung, M Wang, LX Na, ZJ Yang*, LR Zhang, AH Guse, LH Zhang*, Chem. Commun. , 2011, 47 , 9462-9464.
5. Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains, JF Xu, ZJ Yang, W Dammermann, LR Zhang, AH Guse, LH Zhang*, J. Med. Chem. , 2006, 49 (19), 5501-12.
6. Synthesis and biological evaluation of novel membrane-permeant cyclicADP-ribose mimics: N1-[(5’’- O -phosphoryl ethoxy)methyl]-5’-O-phosphorylinosine 5’,5’’-cyclicpyrophosphate (cIDPRE) and 8-substituted derivatives , XF Gu, ZJ Yang, LR Zhang, S Kunerth, R Fliegert, K. Weber, AH Guse, LH Zhang*, J. Med. Chem. , 2004, 47, 5674-5682.
More: http://sklnbd.bjmu.edu.cn/team/scientific_research_team/27.html
