Associate Professor

Research Areas

Carbohydrate Chemistry

Carbohydrate-based drug discovery

Education & Positions

Lanzhou University, B.S., 2005

Peking University, Ph.D., 2010

Peking University, Assistant Professor 2010-2016,

Associate Professor 2016-

Faculty Accolades

The State Natural Science Award, P. R. China 2013, second class, second achiever

Science and Technology Award of Chinese Pharmaceutical Association, P. R. China 2011, first class, second achiever

Natural Science Award of Ministry of Education, P. R. China 2010, second class, second achiever

The national youth talent support program (2021)

Research Interests

Our research programs focus on carbohydrate chemistry and carbohydrate-based drug discovery. We developed a series of novel photo-induced glycosylation methods and continue to study the synthesis and evaluation of biologically important oligosaccharides. We also explore new methodologies for the preparation of carbohydrate mimetics, such as C -glycosyl compounds, fluorinated sugars, and continue to investigate their biological activities.

Grants and fundings

1. Project of National Natural Science Foundation of China, 22177003, 01/01/2022-12/31/2025, PI.

2. Project of National Natural Science Foundation of China, 21977003, 01/01/2020-12/31/2023, PI.

3. Project of National Natural Science Foundation of China, 21772006, 01/01/2018-12/31/2021, PI.

4. Project of National Natural Science Foundation of China, 21572012, 01/01/2016-12/31/2019, PI.

5. Project of Beijing Natural Science Foundation, 2142015, 01/01/2014-6/31/2016, PI.

6. Beijing Higher Education Young Elite Teacher Project, YETP006301/10/2013-12/31/2015, PI.

7. Project of National Natural Science Foundation of China, 21102008, 01/01/2012-12/31/2014, PI.

Publications

1. Kai-Meng Liu, Peng-Yu Wang, Zhen-Yan Guo, De-Cai Xiong*, Xian-Jin Qin, Miao Liu, Meng Liu, Wan-Ying Xue, and Xin-Shan Ye*, “Iterative Synthesis of 2-Deoxyoligosaccharides Enabled by Stereoselective Photoredox-catalyzed Glycosylation”, Angew. Chem. Int. Ed., 2022, DOI: 10.1002/anie.202114726.
2. Yafei Cao⁺, Minmin Zhou⁺, Run-Ze Mao, You Zou, Feng Xia, Da-Ke Liu, Jianhui Liu, Qin Li, De-Cai Xiong*, Xin-Shan Ye*, “Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation”, Chem. Commun., 2021, 57, 10899-10902.
3. Zhao-Xiang Luo⁺, Miao Liu⁺, Tian Li, De-Cai Xiong*, Xin-Shan Ye*, “Electrochemical Bromination of Glycals”, Front. Chem., 2021, 9, 796690.
4. Miao Liu⁺, Kai-Meng Liu⁺, De-Cai Xiong*, Hanyu Zhang, Tian Li, Bo-Han Li, Xianjin Qin, Jinhe Bai, Xin-Shan Ye*, “Stereoselective Electro-2-Deoxyglycosylation from Glycals”, Angew. Chem. Int. Ed., 2020, 59, 15204-15208.
5. Bo-Han Li⁺, Wenlong Yao⁺, Hong Yang⁺, Congying Wu, De-Cai Xiong*, Yuxin Yin*, Xin-Shan Ye*, "Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation”,Org. Chem. Front., 2020, 7, 1255-1259. (⁺co-first author)
6. Shengbiao Tang, Qiannan Zheng, De-Cai Xiong,* Shende Jiang, Qin Li, Xin-Shan Ye*, “Stereocontrolled Synthesis of 2-Deoxy-C-Glycopyranosyl Arenes Using Glycals and Aromatic Amines”, Org. Lett. 2018, 20, 3079-3082.
7. Bang Wang, De-Cai Xiong*, and Xin-Shan Ye*, “Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis”, Org. Lett. 2015, 17, 5698-5701.
8. Run-Ze Mao⁺, Fan Guo⁺, De-Cai Xiong*, Qin Li, Jinyou Duan, and Xin-Shan Ye*, “Photoinduced C–S Bond Cleavage of Thioglycosides and Glycosylation”, Org. Lett. 2015, 17, 5606-5609. (⁺co-first author)