Professor
Research Areas
Medicinal Chemistry
Education & Positions
University of Science and Technology of China (USTC), B.S., 1994 Massachusetts Institute of Technology, Ph.D., 2000 Beijing Medical University, Undergraduate Student, BS, 1980-1985
Beijing Medical University, Graduated Student, PhD, 1985-1989 Beijing Medical University, Assistant Professor 1990-1993
Tokushima University, Japan, Visiting Scholar, 1993-1994
Beijing Medical University, Associate Professor 1994-1995
University of California at San Francisco, USA, Visiting Scholar, 1995-1996
Beijing Medical University, Associate Professor 1997-2000
Peking University Health Science Center, Associate Professor 2000-2002, Professor 2002- Vice Director, Department of Medicinal Chemistry, 1997-2010 Vice Dean, School of Pharmaceutical Sciences, 2009-2015 Secretary of the Party Committee, School of Pharmaceutical Sciences, 2010-
Research Interests
Anti-Alzheimer’s disease, anticancer, antiviral and cardiovascular agents
Protease inhibitors, kinase inhibitors, CGRP agonists/antagonists
Molecular drug design, QSAR, organic synthesis, bioactivity evaluation
Grants and Fundings
National Natural Science Foundation of China (21172012, 20772008, 20572006, 20272004, 20342003, 39800186)
National Basic Research Program of China (973 Program, 2012CB518002, G1998051114)
Specialized Research Fund for the Doctoral Program of Higher Education of China (20120001110010)
Beijing Natural Science Foundation (7162110, 7112088)
Principal Investigator
Publications
1.Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*. 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies. European Journal of Medicinal Chemistry, 2017, 137(7): 462-475.
2. Yuanjun Zhu, Tongliang Zhou, Lingfei Yang, Lan Yuan, Lei Liang*, Ping Xu*. Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochemical and Biophysical Research Communications, 2017, 486: 904-908.
3. Tongliang Zhou, Lingfei Yang, Lei Liang*, Hui Liu, Yuanjun Zhu*, Mengyang Shui, Lan Yuan*, Fengrong Xu, Yan Niu, Chao Wang and Ping Xu*. Rational Design of a Near-Infrared Fluorescent Probe Based on a Pyridazinone Scaffold. European Journal of Organic Chemistry, 2017, 3274-3281.
4. Hongyue Li, Tongliang Zhou, Hui Liu, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang*, Ping Xu*. Discovery of a cobalt complex with high MEK1 binding affinity. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 2221-2224.
5. Tongliang Zhou, Yuanbo Cai, Lei Liang*, Lingfei Yang, Fengrong Xu, Yan Niu, Chao Wang, Jun-Long Zhang*, Ping Xu*. Discovery of a potent and highly specific β2 proteasome inhibitor from a library of copper complexes. Bioorganic & Medicinal Chemistry Letters, 2016, 26: 5780-5784.
6. Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*. Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents. Bioorganic & Medicinal Chemistry, 2016, 24(16): 3472-3482.
7. Lingfei Yang, Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Jun-Long Zhang, Ping Xu*, Lan Yuan* and Lei Liang*. Rational Design of Fluorescent hthalazinone Derivatives for One and Two-Photon Imaging. Chemistry-A European Journal, 2016, 22(35): 12363-12370.
8. Lingfei Yang, Wei Wang, Qi Sun, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang* and Ping Xu*. Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorganic & Medicinal Chemistry Letters, 2016, 26(12): 2801-2805.
9. Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin* and Ping Xu*. Synthesis, bioactivity, docking and molecular dynamic studies of furan-based peptidic molecules as 20S proteasome inhibitors. ChemMedChem, 2015, 10(3): 498-510.
10. Wei Wang, Lei Liang*, Fengrong Xu, Wenjie Huang, Yan Niu, Qi Sun and Ping Xu*. A Ruthenium Catalyzed Switchable N-H/C-H Alkenylation of 6-Phenyl Dihydropyridazinones with Alkynes. European Journal of Organic Chemistry, 2014, 2014(31): 6863-6867.
11. Peng Liu, Yan Niu*, Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu, Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*. 4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies. European Journal of Medicinal Chemistry, 2014, 79: 413-421.
12. Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu*, and Ping Xu*. Rational Design, Green Synthesis, and Initial Evaluation of a Series of Full-Color Tunable Fluorescent Dyes Enabled by the Copper-Catalyzed N-Arylation of 6-Phenyl Pyridazinones and Their Application in Cell Imaging. Chemistry-A European Journal, 2013, 19: 13774-13782.
13. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun and Ping Xu*. Copper-Catalyzed Aerobic Dehydrogenation of C-C to C="C" Bond in the Synthesis of Pyridazinones. European Journal of Organic Chemistry, 2013, 27: 6130-6136.
14. Chao Wang, Fengrong Xu*, Yan Niu*, Yun Wu, Jing Sun, Yihong Peng, Lei Liang and Ping Xu*. Synthesis and Biological Evaluations of 3-Benzothiazol-2-yl Coumarin Derivatives as MEK1 Inhibitors. Letters in Drug Design & Discovery, 2013, 10(8): 727-732.
15. Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu*, Yun Wu, Xin Wang, Yihong Peng, Jing Sun, Lei Liang1 and Ping Xu*. Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents. Molecules. 2013, 18: 6057-6091.
16. Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun and Ping Xu*. Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation. Organic Letters. 2013, 15(11): 2770-2773.
17. Liang, L.; Yang, G.; Wang, W.; Xu, F.; Niu, Y.; Sun, Q.; Xu, P.* A Copper-catalyzed Aerobic Cascade Dehydrogenative-dehalogenative Reaction. Advanced Synthesis & Catalysis. 2013, 355: 1284-1290.
18. Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun and Ping Xu*. Design, Synthesis and In Vitro Biological Evaluation of 3- styrylbenzimidamides as Potential BACE1 Inhibitors. Letters in Drug Design & Discovery. 2013, 10(4): 297-302.
19. Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun and Ping Xu*. Synthesis, in vitro Biological Evaluation and Molecular Docking Studies of Benzimidamides as Potential BACE1 Inhibitors. Chemical Biology & Drug Design. 2012, 80: 775-780.
20. Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu*. The Discovery of Novel b-Secretase Inhibitors: Phaemacophore Modeling, Virtual Screening, and Docking Studies. Chemical Biology & Drug Design, 2012, 79(6): 972-98
