Education:

1981-1985           B.Sc., Chemistry, Wuhan University, Wuhan, China

1985-1988           M.Sc., Organic Chemistry, Wuhan University, Wuhan, China                   

1993-1996           Ph.D., Organic Chemistry, The Chinese University of Hong Kong, Hong Kong

1996-2000           Research Associate, The Scripps Research Institute, La Jolla, California, USA

 

Teaching :          Advanced Organic Chemistry

                           

Professional:          

1988-1993          Lecturer of Chemistry, Huazhong Agricultural University

2000-                  Professor of Medicinal Chemistry, Peking University

 

Research Interests:

(1) Development of new methodologies or strategies for assembly of oligosaccharides;

(2) Synthesis and evaluation of biologically important oligosaccharides such as tumor-associated antigens;

 (3) Chemical modifications of aminoglycoside antibiotics;

(4) Design, synthesis and evaluation of carbohydrate-processing enzyme inhibitors as well as discovery of new carbohydrate-based drugs.

 

JOURNAL EDITING ACTIVITIES

Member of Editorial Board of Carbohydrate Research (2009-)

Member of Editorial Board of Chinese Journal of Organic Chemistry (2007-)

Member of Editorial Board of Chemical Journal of Chinese Universities (2007-)

Member of Editorial Board of Chinese Journal of Medicinal Chemistry (2006-)

Member of Editorial Board of Chinese Journal of New Drugs (2009-)

Member of Editorial Board of Acta Scientiarum Naturalium Universitatis Pekinensis (2005-)

Associate Editor-in-Chief of Journal of Chinese Pharmaceutical Sciences (2005-)

 

Selected Publication:

1.        Xuefei Huang, Lijun Huang, Haisheng Wang, Xin-Shan Ye, “Iterative one-pot synthesis of oligosaccharides”, Angew. Chem. Int. Ed., 2004, 43, 5221-5224.

2.        Haisheng Wang, Ji She, Li-He Zhang, Xin-Shan Ye, “Silver(I) oxide mediated selective monoprotection of diols in pyranosides”, J. Org. Chem., 2004, 69, 5774-5777.

3.        Yuhang Wang, Xuefei Huang,  Li-He Zhang, Xin-Shan Ye, “A four-component one-pot synthesis of α-Gal pentasaccharide”, Org. Lett., 2004, 6, 4415-4417.

4.        Yuan Wang, Qin Li, Shuihong Cheng, Yanfen Wu, Dongjie Guo, Qiu-Hua Fan, Xiaofang Wang, Li-He Zhang, Xin-Shan Ye, “Base-Promoted Rearrangement of Sugar Epoxides to Unsaturated Sugars”, Org. Lett. 2005, 7, 5577-5579.

5.        Xin-Shan Ye, Fang Sun, Min Liu, Qin Li, Yuhang Wang, Guisheng Zhang, Li-He Zhang, Xiao-Lian Zhang, “Synthetic iminosugar derivatives as new potential immunosuppressive agents”, J. Med. Chem., 2005, 48, 3688-3691.

6.        Qiu-Hua Fan, Nan-Ting Ni, Qin Li, Li-He Zhang, Xin-Shan Ye, “New One-Carbon Degradative Transformation of b-Alkyl-b-azido Alcohols”, Org. Lett. 2006, 8, 1007-1009.

7.        Jian Zhou, Guannan Wang, Li-He Zhang, Xin-Shan Ye, “Modifications of Aminoglycoside Antibiotics Targeting RNA”, Med. Res. Rev., 2007, 27, 279-316.

8.        Yiqun Geng, Li-He Zhang, Xin-Shan Ye，“Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamine donors”, Chem. Commun., 2008, 597-599.

9.        De-Cai Xiong, Li-He Zhang, and Xin-Shan Ye*, “Bromodimethylsulfonium bromide-silver triflate: a new powerful promoter system for the activation of thioglycosides”, Adv. Synth. Catal. 2008, 350, 1696-1700.

10.    Yin-Suo Lu, Qin Li, Li-He Zhang, and Xin-Shan Ye*, “Highly Direct α-Selective Glycosylations of 3,4-O-Carbonate-Protected 2-Deoxy and 2,6-Dideoxythioglycosides by Preactivation Protocol”, Org. Lett. 2008, 10, 3445-3448.

11.    Guan-Nan Wang, Gabriele Reinkensmeier, Siwei Zhang, Jian Zhou, Liangren Zhang, Li-He Zhang, Terry D. Butters* and Xin-Shan Ye*, “Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease”, J. Med. Chem., 2009, 52, 3146-3149.

12.    De-Cai Xiong, Li-He Zhang, and Xin-Shan Ye*, “Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-Glycosides”, Org. Lett., 2009, 11, 1709-1712.

13.    Lin Yang and Xin-Shan Ye*, “Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains”, Curr. Top. Med. Chem., 2010, 10, 1898-1926.

14.    Fan Yang, Xiu-Jing Zheng, Chang-Xin Huo, Yue Wang, Ye Zhang*, and Xin-Shan Ye*, “Enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of STn antigen”, ACS Chem. Biol., 2011, 6, 252-259.

15.    Guan-Nan Wang, Lin Yang, Li-He Zhang, and Xin-Shan Ye*, “A Versatile Approach to N-Alkylated 1,4-Dideoxy-1,4-Imino-D-Arabinitols and 1,4-Dideoxy-1,4-Imino-L-Xylitols”, J. Org. Chem., 2011, 76, 2001-2009.

16.    Guan-Nan Wang, Yulan Xiong, Jia Ye, Li-He Zhang, and Xin-Shan Ye*, “Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents”, ACS Med. Chem. Lett. 2011, 2, 682-686.

 

Homepage：http://sklnbd.bjmu.edu.cn/plus/list.php?tid=423