Xu Ping

Professor, Ph.D.

Vice Dean of School of Pharmaceutical Sciences, Peking University Health Science Center

 

Address

Department of Medicinal Chemistry

School of Pharmaceutical Sciences

Peking University Health Science Center

Xue Yuan Road #38, Haidian District

Beijing 100191, China

Phone: +86-10-82801505

Fax: +86-10-82801117

E-mail: pingxu@bjmu.edu.cn

 

Experiences

1980-1985, Undergraduate student, B.S., School of Pharmaceutical Sciences, Beijing Medical University, China

1985-1989, Gradute student, Ph.D., School of Pharmaceutical Sciences, Beijing Medical University, China

1989-1993, Lecturer, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, China

1993-1994, Visiting Scholar, Tokushima University, Japan

1994-1995, Associate Professor, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, China

1995-1996, Visiting Scholar, University of California at San Francisco, USA

1997-2000, Associate Professor and Vice-chair, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, China

2000-2002, Associate Professor and Vice-chair, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, China

2002-2009, Professor and Vice-chair, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, China

2009-present, Professor and Vice Dean, School of Pharmaceutical Sciences, Peking University, China

 

Teaching Courses

Medicinal Chemistry (national quality course)

Advanced Medicinal Chemistry

Combinatorial Chemistry and Drug Design

Progress on Medicinal Chemistry

 

Projects on education and teaching reform

1. Postgraduate development of pharmaceutical students with long length of schooling

2. Pattern design and practice of medicinal chemistry experiment course

3. Building up a medicinal chemistry curriculum for pharmaceutical students with long length of schooling

4. National quality course-Medicinal Chemistry, 2006

 

Research Areas

Anti-Alzheimer’s disease, anticancer, antiviral and cardiovascular agents

Protease inhibitors, kinase inhibitors

Molecular drug design, QSAR, organic synthesis

 

Reasearch projects (near 3 years)

1. The basic research on new GPCR drug targets related to major cardiovascular diseases-The actions of endogenous vascular active substances and their GPCR on atherosclerosis. 973 project. 2012-2016

2. Research on MEK inhibitors as novel antiviral drugs. National Natural Science Foundation. 2012.1-2015.12

3. Design, synthesis and modification of new anticancer proteasome inhibitors. Beijing Natural Science Foundation. 2011.1-2013.12

4. Design, synthesis and modification of b-protease inhibitors as anti-Alzhemer’s disease drugs. National Natural Science Foundation. 2008.1-2010.12

5. Design, synthesis and modification of new anticancer proteasome inhibitors. National Natural Science Foundation. 2008.1-2010.12

 

Representative articles

1.        Gang Fu, Robert J. Doerksen*, Ping Xu*. Assignment of absolute configuration of sulfinyl dilactones: Optical rotations and 1H NMR experiment and DFT calculations. Journal of Molecular Structure. 2011, 987: 166-173.

2.        Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry. 2010, 45(5): 2089-2094.

3.        Yue Yuan, Xiao-Min Zou, Yan Niu, Feng-Rong Xu, Ke Mou, Bo Zhou, Chao Wang, Yong-Jian Li, Guan-Yu Yang and Ping Xu*. Synthesis of acyclic analogs of Syringolin A as potential 20S proteasome inhibitors. Journal of Chinese Pharmaceutical Sciences. 2010, 19(6): 423-435.

4.        Wenjing Chen, Ke Mou, Bo Xu, Xiaomei Ling*, Jingrong Cui, Ping Xu*. Capillary electrophoresis for screening of 20S proteasome inhibitors. Analytical Biochemistry. 2009, 394 (1): 62–67.

5.        Ke Mou, Bo Xu, Chao Ma, Xiaoming Yang, Xiaomin Zou, Yang Lü, Ping Xu*. Novel CADD-based Peptidyl Vinyl Ester Derivatives as Potential Proteasome Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18(8): 2198-2202.

6.        Yiqiu Fu, Bo Xu, Xiaomin Zou, Chao Ma, Xiaoming Yang, Ke Mou, Gang Fu, Yang Lü, Ping Xu*. Design and Synthesis of A Novel Class of Furan-based Molecules as Potential 20S Proteasome Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2007, 17(4): 1102-1106.

7.        Xiaoming Yang, Xiaomin Zou, Yiqiu Fu, Ke Mou, Gang Fu, Chao Ma and Ping Xu*. Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylene Dipeptide Isostere. Synthetic Communications. 2007, 37(1): 9-24.

8.        Xin Zhang, Xiaomin Zou and Ping Xu*. TEMPLATE SYNTHESIS OF PEPTIDOMIMETICS COMPOSED OF ASPARTIC ACID MOIETY BY UGI FOUR-COMPONENT CONDENSATION REACTION. Synthetic Communications. 2005; 35(14): 1881-1888.

9.        Wen Hao WANG, Xiao Min ZOU, Xin ZHANG, Yi Qiu FU, Ping XU*. Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction. Chinese Chemical Letters. 2005; 16(5): 585-588.

10.    Ping Xu,* Ting Zhang, Wenhao Wang, Xiaomin Zou, Xin Zhang, Yiqiu Fu. Synthesis of PNA Monomers and Dimers by Ugi Reaction. Synthesis (Stuttgart). 2003；June(8)：1171-1176.

11.    Ping Xu*, Wenwei Lin, Xiaomin Zou. Synthesis of a Peptidomimetic HCMV Protease Inhibitor Library. Synthesis (Stuttgart). 2002；June(8)：1017－1026.