牛彦 理学博士，副教授，硕士生导师
办公电话: +86-10-82805281 电子邮箱: yanniu@bjmu.edu.cn
学习经历
2015.9-2016.9 德国康斯坦茨大学化学生物学与药理学系,访问学者
2013.8-今 北京大学药学院,药物化学系,副教授,硕士生导师;
2007.8-2013.7 北京大学药学院,药物化学系,讲师;
2002.9-2007.7 北京大学药学院,化学生物学专业,博士;
1998.9-2002.7 北京大学药学院,药学专业,本科。
讲授课程
《药物化学》、《药物化学进展》、《计算机辅助药物设计》。
研究方向与兴趣
1. 药物先导化合物的发现和优化；
2. 基于靶标结构的药物分子设计与化学合成；
3. 活性小分子构效关系研究
获得奖励
1.2008年,药学院第八届青年教师教学演示竞赛,二等奖
2.2009年,北京大学医学部,优秀教师奖
3.2010年,北京大学优秀班主任,二等奖
4.2010年,北京大学药学院,优秀共产党员
代表性论文
Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*, 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, European Journal of Medicinal Chemistry, 2017, 137: 462–475
Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*, Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Bioorganic & Medicinal Chemistry, 2016, 24: 3472–3482
Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin*, Ping Xu*. Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors. ChemMedChem, 2015, 10, 498–510.
Peng Liu, Yan Niu,* Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu,Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*, 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies, European Journal of Medicinal Chemistry. 2014, 79: 413- 421.
Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu* , Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents, Molecules, 2013, 18, 6057-6091.
Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors, Letters in Drug Design & Discovery, 2013, 10 (4): 297-302
Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors, Chem Biol Drug Des, 2012, 80: 775–780
Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies, Chem Biol Drug Des, 2012, 79:972-80
Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu, Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline, Biochemical and Biophysical Research Communications, 2011, 410: 229–234
Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry. 2010, 45: 2089–2094
Bo Zhou, Yan Niu, Xiao-Min Zou, Feng-Rong Xu, Yue Yuan, Chao Wang, Hai-Fei Gao, Peng Liu, Ping Xu*, Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors, Journal of Chinese Pharmaceutical Sciences, 2010, 19 (5): 391-400.
Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice, Neuroscience Letters, 2010, 473: 115–119
Yihui Cui, Dong Wang, Wen Si, Wen Lu, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline, Cell Research, 2008: 1-3
中国专利
(1) 徐萍，彭宜红，王超，牛彦，张浩，许凤荣，具有MEK抑制功能的化合物及其制备方法与应用，2015.11.18-2035.11.19，中国，CN201210440137.X;
(2) 徐萍，牛彦，高海飞，许凤荣，具有β-分泌酶抑制功能的化合物及其制备方法与应用，2013.4.3-2031.9.20，中国，CN201110279736.3
