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YE Xinshan

Professor

Changjiang Professor

Research Areas

Chemical Biology

Medicinal Chemistry

 

Education & Positions

University of Science and Technology of China (USTC), B.S., 1994 Massachusetts Institute of Technology, Ph.D., 2000 Wuhan University, B.S., 1985

Wuhan University, M.S., 1988

Huazhong Agricultural University, Lecturer, 1988-1993

The Chinese University of Hong Kong, Ph.D., 1996

The Scripps Research Institute, Research Associate, 1996-2000 Peking University, Changjiang Professor 2000- Director, State Key Laboratory of Natural and Biomimetic Drugs, 2005-2012 Invited Professor, Université Pierre et Marie Curie, 2012.07-2012.08 Deputy Dean, School of Pharmaceutical Sciences, 2016-

 

Faculty Accolades

National Outstanding Young Investigator Award by Natural Science Foundation of China (2005)

Science and Technology Award of Chinese Pharmaceutical Association, First Class (2011)

The 13th Wu Jieping-Paul Janssen Medical & Pharmaceutical Award (2012)

The State Natural Science Award, Second Class (2013)

Zhang Shuzheng Memorial Award in Glycoscience for the Outstanding Achievements, Chinese Society for Biotechnology(2015)

Chinese Chemical Society Zhou Weishan Memorial Award in Natural Product Synthesis (2017)

 

Research Interests

The research of the Ye group deals with chemical glycobiology and carbohydrate-based drug discovery. The research interests include the development of new methodologies or strategies for the assembly of glycans, the synthesis and evaluation of biologically important oligosaccharides such as tumor-associated antigens, the synthesis of carbohydrate mimetics/glycoconjugates and their therapeutical applications, as well as the design, synthesis and evaluation of carbohydrate-processing enzyme inhibitors.

 

Grants and Fundings

Key project of National Natural Science Foundation of China (21738001, RMB 3,000,000, PI)

Project of National Natural Science Foundation of China (81473084, RMB 1,000,000, PI)

National key research and development program (2018YFA0507600, RMB 26,710,000, participant)

 

Publications

1.Yong Wu, De-Cai Xiong, Si-Cong Chen, Yong-Shi Wang, Xin-Shan Ye*, Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units, Nat. Commun. , 2017, 8 , 14851.

2.Jian Guo,Wenming Li, Weiwei Xue, Xin-Shan Ye*, Transition state-based sialyltransferase inhibitors: mimicking oxocarbenium ion by simple amide, J. Med. Chem. , 2017, 60 , 2135-2141.

3.Lifeng Sun, Xiaowei Wu, De-Cai Xiong, Xin-Shan Ye*, Stereoselective Koenigs–Knorr glycosylation catalyzed by urea, Angew. Chem. Int. Ed. , 2016, 55 , 8041-8044.

4.Chang-Cheng Liu, Canjia Zhai, Xiu-Jing Zheng, Xin-Shan Ye*, Altering the specificity of the antibody response to HIV gp120 with a glycoconjugate antigen, ACS Chem. Biol. , 2016, 11 , 1702-1709.

5.Wenming Li, Youhong Niu, De-Cai Xiong, Xiaoping Cao, Xin-Shan Ye*, Highly substituted cyclopentane-CMP conjugates as potent sialyltransferase inhibitors, J. Med. Chem. , 2015, 58 , 7972-7990.

 

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