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ZHANG Lihe

Professor, Member of CAS

 

Member of the Chinese Academy of Sciences, Professor

Research Areas

Chemical Biology; Organic Chemistry

 

Education & Positions

Massachusetts Institute of Technology, Ph.D., 2000

University Education:

1964-1967      Graduate School, Beijing Medical College, China. Major in Medicinal Chemistry, MS

1954-1958      Department of Pharmacy, Beijing Medical College, China. BA

Professional Experience:

2006-date      President, Academic Committee of State Key Laboratory of Natural & Biomimetic   Drugs, Peking University

2000-date              Professor of Medicinal Chemistry, Peking University

1992-2006      Director, State Key Laboratory of Natural and Biomimetic Drugs, Peking University

1998-2006      Director, Chemistry Department, National Natural Science Foundation of China

1986-2000      Dean, Professor of Medicinal Chemistry, School of Pharmaceutical Sciences, Beijing Medical University

1983-1986      Associate Professor, School of Pharmaceutical Sciences, Beijing Medical University

1981-1983      Research Associate, Department of Chemistry, University of Virginia, USA

1967-1981      Lecturer, Department of Pharmacy, Beijing Medical College

1958-1964      Assistant, Department of Pharmacy, Beijing Medical College

 

Faculty Accolades

2013    "CAI Yuanpei Award", the highest honor for teachers of Peking University

2012    "Beijing Outstanding people’s Teacher" the highest honor for teachers in Beijing

2009    Nagai-Hisamitsu Outstanding Science Award, Asia Pharmaceutical Association, Kyoto, Japan

2004    Natural Science Award, Second Prize, Ministry of Science and Technology, China

2002    Science and Technology Award, Second Prize, awarded by The Ministry of Education, China

2000    Millennium Pharmaceutical Scientist Award, FIP, San Francisco, USA

1999    He-Liang-He-Li Prize

1998    Science and Technology Award, First Prize, awarded by The Ministry of Education, China

1996    Science and Technology Award, Second Prize, awarded by The Ministry of Education, China

1964  National Award for Scientific Research Excellence, State Commission Science & Technology, China

 

Research Interests

Chemistry of Nucleoside, Nucleotide and Oligonucleotide; Anticancer and Antiviral Drug; Natural Product.

 

Publications

Over 350 in refereed journals. Selected Publications:

1. Identifying glyceraldehyde 3-phosphate dehydrogenase as a cyclic adenosine diphosphoribose binding protein by photoaffinity protein-ligand labeling approach, KH Zhang, W Sun, LH Huang, KY Zhu, F Pei, LC Zhu, Q Wang, YY Lu, HM Zhang, HW Jin, LH Zhang*, LR Zhang*, JB Yue*, J. Am. Chem. Soc. , 2017, 139(1), 156-170.

2.  Generation of influenza A viruses as live but replication-incompetent virus vaccines, LL Si, H Xu, XY Zhou, ZW Zhang, ZY Tian, Y Wang, YM Wu, B Zhang, ZL Niu, CL Zhang, G Fu, SL Xiao, Q Xia, LH Zhang, DM Zhou*, Science , 2016, 354 (6316), 1170-1173

3.  The effects of conformational alteration induced by D-/L-isonucleoside incorporation in siRNA on their stability in serum and silencing activity, Y Huang, Z Chen, Y Chen, H Zhang, YC Zhang, YL Zhao, ZJ Yang*, LH Zhang*, Bioconjugate Chem. , 2013, 24 , 951-959.

4.  A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge, N Qi,  K Jung, M Wang, LX Na, ZJ Yang*, LR Zhang, AH Guse, LH Zhang*, Chem. Commun. , 2011, 47 , 9462-9464.

5. Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains, JF Xu, ZJ Yang, W Dammermann, LR Zhang, AH Guse, LH Zhang*, J. Med. Chem. , 2006, 49 (19), 5501-12.

6. Synthesis and biological evaluation of novel membrane-permeant cyclicADP-ribose mimics: N1-[(5’’- O -phosphoryl ethoxy)methyl]-5’-O-phosphorylinosine 5’,5’’-cyclicpyrophosphate (cIDPRE) and 8-substituted derivatives , XF Gu, ZJ Yang, LR Zhang, S Kunerth, R Fliegert, K. Weber, AH Guse, LH Zhang*, J. Med. Chem. , 2004, 47, 5674-5682.

 

More: http://sklnbd.bjmu.edu.cn/team/scientific_research_team/27.html